| http://purl.uniprot.org/citations/22082077 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22082077 | http://www.w3.org/2000/01/rdf-schema#comment | "Molecular misreading allows the formation of mutant proteins in the absence of gene mutations. A mechanism has been proposed by which a frameshift mutant of the ubiquitin protein, Ubb(+1) , which accumulates in an age-dependent manner as a result of molecular misreading, contributes to neuropathology in Alzheimer's disease (Lam et al. 2000). Specifically, in the Ubb(+1) -mediated proteasome inhibition hypothesis Ubb(+1) 'caps' unanchored (that is, nonsubstrate linked) polyubiquitin chains, which then act as dominant inhibitors of the 26S proteasome. A review of subsequent literature indicates that this original hypothesis is broadly supported, and offers new insights into the mechanisms accounting for the age-dependent accumulation of Ubb(+1) , and how Ubb(+1) -mediated proteasome inhibition may contribute to Alzheimer's disease. Further, recent studies have highlighted a physiological role for free endogenous unanchored polyubiquitin chains in the direct activation of certain protein kinases. This raises the possibility that Ubb(+1) -capped unanchored polyubiquitin chains could also exert harmful effects through the aberrant activation of tau or other ubiquitin-dependent kinases, neuronal NF-κB activity or NF-κB-mediated neuroinflammatory processes."xsd:string |
| http://purl.uniprot.org/citations/22082077 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2990.2011.01236.x"xsd:string |
| http://purl.uniprot.org/citations/22082077 | http://purl.uniprot.org/core/author | "Layfield R."xsd:string |
| http://purl.uniprot.org/citations/22082077 | http://purl.uniprot.org/core/author | "Strachan J."xsd:string |
| http://purl.uniprot.org/citations/22082077 | http://purl.uniprot.org/core/author | "Chadwick L."xsd:string |
| http://purl.uniprot.org/citations/22082077 | http://purl.uniprot.org/core/author | "Gentle L."xsd:string |
| http://purl.uniprot.org/citations/22082077 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22082077 | http://purl.uniprot.org/core/name | "Neuropathol Appl Neurobiol"xsd:string |
| http://purl.uniprot.org/citations/22082077 | http://purl.uniprot.org/core/pages | "118-131"xsd:string |
| http://purl.uniprot.org/citations/22082077 | http://purl.uniprot.org/core/title | "Review: unchained maladie - a reassessment of the role of Ubb(+1) -capped polyubiquitin chains in Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/22082077 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/22082077 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22082077 |
| http://purl.uniprot.org/citations/22082077 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22082077 |
| http://purl.uniprot.org/uniprot/#_B4DV12-mappedCitation-22082077 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22082077 |
| http://purl.uniprot.org/uniprot/#_P0CG47-mappedCitation-22082077 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22082077 |
| http://purl.uniprot.org/uniprot/#_Q5U5U6-mappedCitation-22082077 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22082077 |
| http://purl.uniprot.org/uniprot/P0CG47 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22082077 |
| http://purl.uniprot.org/uniprot/Q5U5U6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22082077 |
| http://purl.uniprot.org/uniprot/B4DV12 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22082077 |