| http://purl.uniprot.org/citations/22082645 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22082645 | http://www.w3.org/2000/01/rdf-schema#comment | "BACKGROUND The mechanisms of tumour progression during anti-VEGF-A treatment are poorly understood. PATIENTS AND MATERIALS Two patients with metastatic breast cancer are described who developed new metastases while receiving anti-VEGF-A treatment. Angiogenic parameters were determined by CD34/Ki67 double staining, Chalkley counts (CC) and endothelial cell proliferation fractions (ECP). RT-PCR Taqman low-density arrays with a gene panel of 94 angiogenesis-related genes were performed on both metastases and compared to 10 unselected primary breast tumours. RESULTS Both lesions showed a high and intermediate CC of, respectively, 7.5±0.62 and 4.8±0.2. Both lesions had elevated ECP values of 14% and 8%. Low-density array screening showed that VEGFR1 mRNA was overexpressed in both samples (z-score=7.85 and 7.81) compared to control samples (out of range [min-max]). Additional analysis confirmed this finding at the protein level by immunohistochemistry. CONCLUSION These observations suggest that tumour progression under continuous anti-VEGF-A continues to be angiogenesis dependent. Further exploration is needed to identify the mechanisms of anti-VEGF-A resistance in order to design combination-targeted therapies."xsd:string |
| http://purl.uniprot.org/citations/22082645 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12094-011-0737-3"xsd:string |
| http://purl.uniprot.org/citations/22082645 | http://purl.uniprot.org/core/author | "Dirix L.Y."xsd:string |
| http://purl.uniprot.org/citations/22082645 | http://purl.uniprot.org/core/author | "Vermeulen P.B."xsd:string |
| http://purl.uniprot.org/citations/22082645 | http://purl.uniprot.org/core/author | "Van Laere S.J."xsd:string |
| http://purl.uniprot.org/citations/22082645 | http://purl.uniprot.org/core/author | "Van den Eynden G.G."xsd:string |
| http://purl.uniprot.org/citations/22082645 | http://purl.uniprot.org/core/author | "van Dam P.A."xsd:string |
| http://purl.uniprot.org/citations/22082645 | http://purl.uniprot.org/core/author | "Tjalma W.A."xsd:string |
| http://purl.uniprot.org/citations/22082645 | http://purl.uniprot.org/core/author | "Trinh X.B."xsd:string |
| http://purl.uniprot.org/citations/22082645 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22082645 | http://purl.uniprot.org/core/name | "Clin Transl Oncol"xsd:string |
| http://purl.uniprot.org/citations/22082645 | http://purl.uniprot.org/core/pages | "805-808"xsd:string |
| http://purl.uniprot.org/citations/22082645 | http://purl.uniprot.org/core/title | "VEGF-A-independent and angiogenesis-dependent tumour growth in patients with metastatic breast cancer."xsd:string |
| http://purl.uniprot.org/citations/22082645 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/22082645 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22082645 |
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| http://purl.uniprot.org/uniprot/#_P17948-mappedCitation-22082645 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22082645 |
| http://purl.uniprot.org/uniprot/#_L7RSL3-mappedCitation-22082645 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22082645 |
| http://purl.uniprot.org/uniprot/#_Q16332-mappedCitation-22082645 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22082645 |
| http://purl.uniprot.org/uniprot/#_Q16333-mappedCitation-22082645 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22082645 |