| http://purl.uniprot.org/citations/22083526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22083526 | http://www.w3.org/2000/01/rdf-schema#comment | "The ability of synthetic oligodeoxynucleotides containing unmethylated cytosine guanine motifs (CpG-ODN) to induce both stimulatory and counter-regulatory responses offers novel opportunities for using these molecules as immunomodulatory agents in different therapeutic strategies. Here, we investigated the potential of CpG-ODN to activate the arginase (ARG) enzyme in vivo and focused on the consequences of this activation in T-cell proliferation. Challenging mice subcutaneously with CpG-ODN emulsified in incomplete Freund's adjuvant (IFA) induced ARG and reduced T-cell proliferation associated with CD3ζ chain downregulation. Interestingly, impaired T-cell expansion correlated with elevated levels of CD11b(+)Gr1(+) myeloid cells localized near T-cell areas in the spleen. In addition, purified CD11b(+) cells obtained from the spleen of CpG-ODN+IFA-treated mice exhibited increased ARG activity and ARG I expression along with an augmented [(3)H]-L-arginine uptake. CD11b(+) myeloid cells significantly suppressed T-cell proliferation and CD3ζ chain expression induced by a polyclonal stimulus. Furthermore, these effects could be recovered by the addition of excess L-arginine or by treatment of CD11b(+) cells with a specific ARG inhibitor. This study provides a novel evidence that CpG-ODN+IFA are able to induce splenic CD11b(+) cells with ARG activity, with this population being responsible for the impaired T-cell proliferation observed after the treatment with CpG-ODN+IFA. These results underscore a key role of CpG-ODN on ARG activity in vivo and add support to the growing body of evidence in favor of a counter-regulatory role for CpG-ODN in an immune response."xsd:string |
| http://purl.uniprot.org/citations/22083526 | http://purl.org/dc/terms/identifier | "doi:10.1038/icb.2011.98"xsd:string |
| http://purl.uniprot.org/citations/22083526 | http://purl.uniprot.org/core/author | "Pistoresi-Palencia M.C."xsd:string |
| http://purl.uniprot.org/citations/22083526 | http://purl.uniprot.org/core/author | "Maletto B.A."xsd:string |
| http://purl.uniprot.org/citations/22083526 | http://purl.uniprot.org/core/author | "Crespo M.I."xsd:string |
| http://purl.uniprot.org/citations/22083526 | http://purl.uniprot.org/core/author | "Gorlino C.V."xsd:string |
| http://purl.uniprot.org/citations/22083526 | http://purl.uniprot.org/core/author | "Harman M.F."xsd:string |
| http://purl.uniprot.org/citations/22083526 | http://purl.uniprot.org/core/author | "Liscovsky M.V."xsd:string |
| http://purl.uniprot.org/citations/22083526 | http://purl.uniprot.org/core/author | "Moron G."xsd:string |
| http://purl.uniprot.org/citations/22083526 | http://purl.uniprot.org/core/author | "Ranocchia R.P."xsd:string |
| http://purl.uniprot.org/citations/22083526 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22083526 | http://purl.uniprot.org/core/name | "Immunol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/22083526 | http://purl.uniprot.org/core/pages | "710-721"xsd:string |
| http://purl.uniprot.org/citations/22083526 | http://purl.uniprot.org/core/title | "Arginase-dependent suppression by CpG-ODN plus IFA-induced splenic myeloid CD11b(+)Gr1(+) cells."xsd:string |
| http://purl.uniprot.org/citations/22083526 | http://purl.uniprot.org/core/volume | "90"xsd:string |
| http://purl.uniprot.org/citations/22083526 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22083526 |
| http://purl.uniprot.org/citations/22083526 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22083526 |
| http://purl.uniprot.org/uniprot/#_Q61176-mappedCitation-22083526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22083526 |
| http://purl.uniprot.org/uniprot/#_Q8K3K5-mappedCitation-22083526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22083526 |
| http://purl.uniprot.org/uniprot/Q61176 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22083526 |
| http://purl.uniprot.org/uniprot/Q8K3K5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22083526 |