| http://purl.uniprot.org/citations/22083956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22083956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22083956 | http://www.w3.org/2000/01/rdf-schema#comment | "Estrogen receptor (ER) and NF-κB are transcription factors with profound effects on breast cancer cell proliferation and survival. While many studies demonstrate that ER and NF-κB can repress each other, we previously identified a gene signature that is synergistically upregulated by these two factors in more aggressive luminal B breast tumors. Herein, we examine a novel mechanism of cross talk between ER and NF-κB that results in the upregulation of the antiapoptotic gene BIRC3 (also known as cIAP2). We demonstrate that NF-κB, acting through two response elements, is required for ER recruitment to an adjacent estrogen response element (ERE) in the BIRC3 promoter. This effect is accompanied by a major increase in NF-κB-dependent histone acetylation around the ERE. Interestingly, CBP, a histone acetyltransferase previously implicated in repressive interactions between ER and NF-κB, plays a permissive role by promoting histone acetylation and ER recruitment, as well as enhanced expression of BIRC3. These findings suggest a new gene regulatory mechanism by which inflammation and NF-κB activation can influence ER recruitment to inherently inactive ER binding sites. This fine-tuning mechanism may explain how two factors that generally repress each other's activity may work together on certain genes to promote breast cancer cell survival and tumor progression."xsd:string |
| http://purl.uniprot.org/citations/22083956 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.05869-11"xsd:string |
| http://purl.uniprot.org/citations/22083956 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.05869-11"xsd:string |
| http://purl.uniprot.org/citations/22083956 | http://purl.uniprot.org/core/author | "Frasor J."xsd:string |
| http://purl.uniprot.org/citations/22083956 | http://purl.uniprot.org/core/author | "Frasor J."xsd:string |
| http://purl.uniprot.org/citations/22083956 | http://purl.uniprot.org/core/author | "Pradhan M."xsd:string |
| http://purl.uniprot.org/citations/22083956 | http://purl.uniprot.org/core/author | "Pradhan M."xsd:string |
| http://purl.uniprot.org/citations/22083956 | http://purl.uniprot.org/core/author | "Baumgarten S.C."xsd:string |
| http://purl.uniprot.org/citations/22083956 | http://purl.uniprot.org/core/author | "Baumgarten S.C."xsd:string |
| http://purl.uniprot.org/citations/22083956 | http://purl.uniprot.org/core/author | "Bembinster L.A."xsd:string |
| http://purl.uniprot.org/citations/22083956 | http://purl.uniprot.org/core/author | "Bembinster L.A."xsd:string |
| http://purl.uniprot.org/citations/22083956 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22083956 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22083956 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/22083956 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/22083956 | http://purl.uniprot.org/core/pages | "569-575"xsd:string |
| http://purl.uniprot.org/citations/22083956 | http://purl.uniprot.org/core/pages | "569-575"xsd:string |
| http://purl.uniprot.org/citations/22083956 | http://purl.uniprot.org/core/title | "CBP mediates NF-kappaB-dependent histone acetylation and estrogen receptor recruitment to an estrogen response element in the BIRC3 promoter."xsd:string |
| http://purl.uniprot.org/citations/22083956 | http://purl.uniprot.org/core/title | "CBP mediates NF-kappaB-dependent histone acetylation and estrogen receptor recruitment to an estrogen response element in the BIRC3 promoter."xsd:string |
| http://purl.uniprot.org/citations/22083956 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/22083956 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/22083956 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22083956 |
| http://purl.uniprot.org/citations/22083956 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22083956 |