| http://purl.uniprot.org/citations/22084313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22084313 | http://www.w3.org/2000/01/rdf-schema#comment | "Colony stimulating factor-1 (CSF-1) and its receptor (CSF-1R) are key regulators of macrophage biology, and their elevated expression in cancer cells has been linked to poor prognosis. CSF-1Rs are thought to function at the plasma membrane. We show here that functional CSF-1Rs are present at the nuclear envelope of various cell types, including primary macrophages, human cancer cell lines, and primary human carcinomas. In response to CSF-1, added to intact cells or isolated nuclei, nucleus-associated CSF-1R became phosphorylated and triggered the phosphorylation of Akt and p27 inside the nucleus. Extracellularly added CSF-1 was also found to colocalize with nucleus-associated CSF-1Rs. All these activities were found to depend selectively on the activity of the p110δ isoform of phosphoinositide 3-kinase (PI3K). This finding was related to the p110δ-dependent translocation of exogenous CSF-1 to the nucleus-associated CSF-1Rs, correlating with a prominent role of p110δ in activation of the Rab5 GTPase, a key regulator of the endocytic trafficking. siRNA-silencing of Rab5a phenocopied p110δ inactivation and nuclear CSF-1 signaling. Our work demonstrates for the first time the presence of functional nucleus-associated CSF-1Rs, which are activated by extracellular CSF-1 by a mechanism that involves p110δ and Rab5 activity. These findings may have important implications in cancer development."xsd:string |
| http://purl.uniprot.org/citations/22084313 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.11-189753"xsd:string |
| http://purl.uniprot.org/citations/22084313 | http://purl.uniprot.org/core/author | "Vanhaesebroeck B."xsd:string |
| http://purl.uniprot.org/citations/22084313 | http://purl.uniprot.org/core/author | "Makrigiannakis A."xsd:string |
| http://purl.uniprot.org/citations/22084313 | http://purl.uniprot.org/core/author | "Papakonstanti E.A."xsd:string |
| http://purl.uniprot.org/citations/22084313 | http://purl.uniprot.org/core/author | "Zwaenepoel O."xsd:string |
| http://purl.uniprot.org/citations/22084313 | http://purl.uniprot.org/core/author | "Tzenaki N."xsd:string |
| http://purl.uniprot.org/citations/22084313 | http://purl.uniprot.org/core/author | "Vergetaki A."xsd:string |
| http://purl.uniprot.org/citations/22084313 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22084313 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/22084313 | http://purl.uniprot.org/core/pages | "691-706"xsd:string |
| http://purl.uniprot.org/citations/22084313 | http://purl.uniprot.org/core/title | "Functional CSF-1 receptors are located at the nuclear envelope and activated via the p110delta isoform of PI 3-kinase."xsd:string |
| http://purl.uniprot.org/citations/22084313 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/22084313 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22084313 |
| http://purl.uniprot.org/citations/22084313 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22084313 |
| http://purl.uniprot.org/uniprot/#_D3YY41-mappedCitation-22084313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22084313 |
| http://purl.uniprot.org/uniprot/#_A0A2K8FKQ1-mappedCitation-22084313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22084313 |
| http://purl.uniprot.org/uniprot/#_A0A2K8FKR1-mappedCitation-22084313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22084313 |
| http://purl.uniprot.org/uniprot/#_A0A2K8FKT1-mappedCitation-22084313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22084313 |
| http://purl.uniprot.org/uniprot/#_A0A2K8FKV1-mappedCitation-22084313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22084313 |
| http://purl.uniprot.org/uniprot/#_A7E2E0-mappedCitation-22084313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22084313 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P8F6-mappedCitation-22084313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22084313 |
| http://purl.uniprot.org/uniprot/#_A0A494BA23-mappedCitation-22084313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22084313 |
| http://purl.uniprot.org/uniprot/#_A0A494BBK8-mappedCitation-22084313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22084313 |