| http://purl.uniprot.org/citations/22085928 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22085928 | http://www.w3.org/2000/01/rdf-schema#comment | "The p53 tumour suppressor protein is a transcription factor that prevents oncogenic progression by activating the expression of apoptosis and cell-cycle arrest genes in stressed cells. The stability of p53 is tightly regulated by ubiquitin-dependent degradation, driven mainly by the ubiquitin ligase MDM2. In this study, we have identified USP42 as a DUB that interacts with and deubiquitinates p53. USP42 forms a direct complex with p53 and controls level of ubiquitination during the early phase of the response to a range of stress signals. Although we do not find a clear role for USP42 in controlling either the basal or fully activated levels of p53, the function of USP42 is required to allow the rapid activation of p53-dependent transcription and a p53-dependent cell-cycle arrest in response to stress. These functions of USP42 are likely to contribute to the repair and recovery of cells from mild or transient damage."xsd:string |
| http://purl.uniprot.org/citations/22085928 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2011.419"xsd:string |
| http://purl.uniprot.org/citations/22085928 | http://purl.uniprot.org/core/author | "Vousden K.H."xsd:string |
| http://purl.uniprot.org/citations/22085928 | http://purl.uniprot.org/core/author | "Carter S."xsd:string |
| http://purl.uniprot.org/citations/22085928 | http://purl.uniprot.org/core/author | "Ludwig R.L."xsd:string |
| http://purl.uniprot.org/citations/22085928 | http://purl.uniprot.org/core/author | "Vigneron A.M."xsd:string |
| http://purl.uniprot.org/citations/22085928 | http://purl.uniprot.org/core/author | "Hock A.K."xsd:string |
| http://purl.uniprot.org/citations/22085928 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22085928 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/22085928 | http://purl.uniprot.org/core/pages | "4921-4930"xsd:string |
| http://purl.uniprot.org/citations/22085928 | http://purl.uniprot.org/core/title | "Regulation of p53 stability and function by the deubiquitinating enzyme USP42."xsd:string |
| http://purl.uniprot.org/citations/22085928 | http://purl.uniprot.org/core/volume | "30"xsd:string |
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