| http://purl.uniprot.org/citations/22086926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22086926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22086926 | http://www.w3.org/2000/01/rdf-schema#comment | "Clinical, pharmacological, biochemical, and genetic evidence support the notion that alteration of cholesterol homeostasis strongly predisposes to Alzheimer disease (AD). The ATP-binding cassette transporter-2 (Abca2), which plays a role in intracellular sterol trafficking, has been genetically linked to AD. It is unclear how these two processes are related. Here we demonstrate that down-regulation of Abca2 in mammalian cells leads to decreased amyloid-β (Aβ) generation. In vitro studies revealed altered γ-secretase complex formation in Abca2 knock-out cells due to the altered levels, post-translational modification, and subcellular localization of Nicastrin. Reduced Abca2 levels in mammalian cells in vitro, in Drosophila melanogaster and in mice resulted in altered γ-secretase processing of APP, and thus Aβ generation, without affecting Notch cleavage."xsd:string |
| http://purl.uniprot.org/citations/22086926 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m111.288258"xsd:string |
| http://purl.uniprot.org/citations/22086926 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m111.288258"xsd:string |
| http://purl.uniprot.org/citations/22086926 | http://purl.uniprot.org/core/author | "Dingwall C."xsd:string |
| http://purl.uniprot.org/citations/22086926 | http://purl.uniprot.org/core/author | "Dingwall C."xsd:string |
| http://purl.uniprot.org/citations/22086926 | http://purl.uniprot.org/core/author | "De Strooper B."xsd:string |
| http://purl.uniprot.org/citations/22086926 | http://purl.uniprot.org/core/author | "De Strooper B."xsd:string |
| http://purl.uniprot.org/citations/22086926 | http://purl.uniprot.org/core/author | "Davis J.B."xsd:string |
| http://purl.uniprot.org/citations/22086926 | http://purl.uniprot.org/core/author | "Davis J.B."xsd:string |
| http://purl.uniprot.org/citations/22086926 | http://purl.uniprot.org/core/author | "Dotti C.G."xsd:string |
| http://purl.uniprot.org/citations/22086926 | http://purl.uniprot.org/core/author | "Dotti C.G."xsd:string |
| http://purl.uniprot.org/citations/22086926 | http://purl.uniprot.org/core/author | "Feiguin F."xsd:string |
| http://purl.uniprot.org/citations/22086926 | http://purl.uniprot.org/core/author | "Feiguin F."xsd:string |
| http://purl.uniprot.org/citations/22086926 | http://purl.uniprot.org/core/author | "Guix F.X."xsd:string |
| http://purl.uniprot.org/citations/22086926 | http://purl.uniprot.org/core/author | "Guix F.X."xsd:string |
| http://purl.uniprot.org/citations/22086926 | http://purl.uniprot.org/core/author | "Michaki V."xsd:string |
| http://purl.uniprot.org/citations/22086926 | http://purl.uniprot.org/core/author | "Michaki V."xsd:string |
| http://purl.uniprot.org/citations/22086926 | http://purl.uniprot.org/core/author | "Munck S."xsd:string |
| http://purl.uniprot.org/citations/22086926 | http://purl.uniprot.org/core/author | "Munck S."xsd:string |
| http://purl.uniprot.org/citations/22086926 | http://purl.uniprot.org/core/author | "Tew K.D."xsd:string |
| http://purl.uniprot.org/citations/22086926 | http://purl.uniprot.org/core/author | "Tew K.D."xsd:string |
| http://purl.uniprot.org/citations/22086926 | http://purl.uniprot.org/core/author | "Townsend D.M."xsd:string |
| http://purl.uniprot.org/citations/22086926 | http://purl.uniprot.org/core/author | "Townsend D.M."xsd:string |