| http://purl.uniprot.org/citations/22095280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22095280 | http://www.w3.org/2000/01/rdf-schema#comment | "Binding of TNF to TNF receptor-1 can give a pro-survival signal through activation of p65/RelA NF-κB, but also signals cell death. To determine the roles of FLICE-inhibitory protein (FLIP) and caspase-8 in TNF-induced activation of NF-κB and apoptosis, we used mouse embryonic fibroblasts derived from FLIP and caspase-8 gene-deleted mice, and treated them with TNF and a smac-mimetic compound that causes degradation of cellular inhibitor of apoptosis proteins (cIAPs). In cells treated with smac mimetic, TNF and Fas Ligand caused wild-type and FLIP(-/-) MEFs to die, whereas caspase-8(-/-) MEFs survived, indicating that caspase-8 is necessary for death of MEFs triggered by these ligands when IAPs are degraded. By contrast, neither caspase-8 nor FLIP was required for TNF to activate p65/RelA NF-κB, because IκB was degraded, p65 translocated to the nucleus, and an NF-κB reporter gene activated normally in caspase-8(-/-) or FLIP(-/-) MEFs. Reconstitution of FLIP(-/-) MEFs with the FLIP isoforms FLIP-L, FLIP-R, or FLIP-p43 protected these cells from dying when treated with TNF or FasL, whether or not cIAPs were depleted. These results show that in MEFs, caspase-8 is necessary for TNF- and FasL-induced death, and FLIP is needed to prevent it, but neither caspase-8 nor FLIP is required for TNF to activate NF-κB."xsd:string |
| http://purl.uniprot.org/citations/22095280 | http://purl.org/dc/terms/identifier | "doi:10.1038/cdd.2011.151"xsd:string |
| http://purl.uniprot.org/citations/22095280 | http://purl.uniprot.org/core/author | "Ahmed A.U."xsd:string |
| http://purl.uniprot.org/citations/22095280 | http://purl.uniprot.org/core/author | "Vaux D.L."xsd:string |
| http://purl.uniprot.org/citations/22095280 | http://purl.uniprot.org/core/author | "Cook W.D."xsd:string |
| http://purl.uniprot.org/citations/22095280 | http://purl.uniprot.org/core/author | "Callus B.A."xsd:string |
| http://purl.uniprot.org/citations/22095280 | http://purl.uniprot.org/core/author | "Khan N.R."xsd:string |
| http://purl.uniprot.org/citations/22095280 | http://purl.uniprot.org/core/author | "Lluis J.M."xsd:string |
| http://purl.uniprot.org/citations/22095280 | http://purl.uniprot.org/core/author | "Moujalled D.M."xsd:string |
| http://purl.uniprot.org/citations/22095280 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22095280 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/22095280 | http://purl.uniprot.org/core/pages | "808-815"xsd:string |
| http://purl.uniprot.org/citations/22095280 | http://purl.uniprot.org/core/title | "In mouse embryonic fibroblasts, neither caspase-8 nor cellular FLICE-inhibitory protein (FLIP) is necessary for TNF to activate NF-kappaB, but caspase-8 is required for TNF to cause cell death, and induction of FLIP by NF-kappaB is required to prevent it."xsd:string |
| http://purl.uniprot.org/citations/22095280 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/22095280 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22095280 |
| http://purl.uniprot.org/citations/22095280 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22095280 |
| http://purl.uniprot.org/uniprot/#_A0A087WQT6-mappedCitation-22095280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22095280 |
| http://purl.uniprot.org/uniprot/#_A0A2C9F2D9-mappedCitation-22095280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22095280 |
| http://purl.uniprot.org/uniprot/#_Q4FK85-mappedCitation-22095280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22095280 |
| http://purl.uniprot.org/uniprot/#_Q3TTS9-mappedCitation-22095280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22095280 |
| http://purl.uniprot.org/uniprot/#_O35732-mappedCitation-22095280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22095280 |
| http://purl.uniprot.org/uniprot/#_Q812G4-mappedCitation-22095280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22095280 |
| http://purl.uniprot.org/uniprot/#_O89110-mappedCitation-22095280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22095280 |
| http://purl.uniprot.org/uniprot/#_Q5U4G3-mappedCitation-22095280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22095280 |