| http://purl.uniprot.org/citations/22096251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22096251 | http://www.w3.org/2000/01/rdf-schema#comment | "Members of the Rac/Rho family of small GTPases play an essential role in phagocytic cells in organization of the actin cytoskeleton and production of toxic oxygen compounds. GTPase-activating proteins (GAPs) decrease the amount of the GTP-bound active form of small GTPases, and contribute to the control of biologic signals. The number of potential Rac/RhoGAPs largely exceeds the number of Rac/Rho GTPases and the expression profile, and their specific role in different cell types is largely unknown. In this study, we report for the first time the properties of full-length ARHGAP25 protein, and show that it is specifically expressed in hematopoietic cells, and acts as a RacGAP both in vitro and in vivo. By silencing and overexpressing the protein in neutrophil model cell lines (PLB-985 and CosPhoxFcγR, respectively) and in primary macrophages, we demonstrate that ARHGAP25 is a negative regulator of phagocytosis acting probably via modulation of the actin cytoskeleton."xsd:string |
| http://purl.uniprot.org/citations/22096251 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2010-12-324053"xsd:string |
| http://purl.uniprot.org/citations/22096251 | http://purl.uniprot.org/core/author | "Geiszt M."xsd:string |
| http://purl.uniprot.org/citations/22096251 | http://purl.uniprot.org/core/author | "Ligeti E."xsd:string |
| http://purl.uniprot.org/citations/22096251 | http://purl.uniprot.org/core/author | "Sirokmany G."xsd:string |
| http://purl.uniprot.org/citations/22096251 | http://purl.uniprot.org/core/author | "Csepanyi-Komi R."xsd:string |
| http://purl.uniprot.org/citations/22096251 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22096251 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/22096251 | http://purl.uniprot.org/core/pages | "573-582"xsd:string |
| http://purl.uniprot.org/citations/22096251 | http://purl.uniprot.org/core/title | "ARHGAP25, a novel Rac GTPase-activating protein, regulates phagocytosis in human neutrophilic granulocytes."xsd:string |
| http://purl.uniprot.org/citations/22096251 | http://purl.uniprot.org/core/volume | "119"xsd:string |
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