| http://purl.uniprot.org/citations/22101514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22101514 | http://www.w3.org/2000/01/rdf-schema#comment | "How the proto-oncogene c-Myc balances the processes of stem-cell self-renewal, proliferation and differentiation in adult tissues is largely unknown. We explored c-Myc's transcriptional roles at the epidermal differentiation complex, a locus essential for skin maturation. Binding of c-Myc can simultaneously recruit (Klf4, Ovol-1) and displace (Cebpa, Mxi1 and Sin3a) specific sets of differentiation-specific transcriptional regulators to epidermal differentiation complex genes. We found that Sin3a causes deacetylation of c-Myc protein to directly repress c-Myc activity. In the absence of Sin3a, genomic recruitment of c-Myc to the epidermal differentiation complex is enhanced, and re-activation of c-Myc-target genes drives aberrant epidermal proliferation and differentiation. Simultaneous deletion of c-Myc and Sin3a reverts the skin phenotype to normal. Our results identify how the balance of two transcriptional key regulators can maintain tissue homeostasis through a negative feedback loop."xsd:string |
| http://purl.uniprot.org/citations/22101514 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb2385"xsd:string |
| http://purl.uniprot.org/citations/22101514 | http://purl.uniprot.org/core/author | "Nichols J."xsd:string |
| http://purl.uniprot.org/citations/22101514 | http://purl.uniprot.org/core/author | "Hussain S."xsd:string |
| http://purl.uniprot.org/citations/22101514 | http://purl.uniprot.org/core/author | "Blanco S."xsd:string |
| http://purl.uniprot.org/citations/22101514 | http://purl.uniprot.org/core/author | "Benitah S.A."xsd:string |
| http://purl.uniprot.org/citations/22101514 | http://purl.uniprot.org/core/author | "Odom D.T."xsd:string |
| http://purl.uniprot.org/citations/22101514 | http://purl.uniprot.org/core/author | "Hendrich B."xsd:string |
| http://purl.uniprot.org/citations/22101514 | http://purl.uniprot.org/core/author | "Frye M."xsd:string |
| http://purl.uniprot.org/citations/22101514 | http://purl.uniprot.org/core/author | "Nascimento E.M."xsd:string |
| http://purl.uniprot.org/citations/22101514 | http://purl.uniprot.org/core/author | "Cox C.L."xsd:string |
| http://purl.uniprot.org/citations/22101514 | http://purl.uniprot.org/core/author | "Trotter M."xsd:string |
| http://purl.uniprot.org/citations/22101514 | http://purl.uniprot.org/core/author | "Suraj M."xsd:string |
| http://purl.uniprot.org/citations/22101514 | http://purl.uniprot.org/core/author | "Kubler B."xsd:string |
| http://purl.uniprot.org/citations/22101514 | http://purl.uniprot.org/core/author | "MacArthur S."xsd:string |
| http://purl.uniprot.org/citations/22101514 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22101514 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/22101514 | http://purl.uniprot.org/core/pages | "1395-1405"xsd:string |
| http://purl.uniprot.org/citations/22101514 | http://purl.uniprot.org/core/title | "The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis."xsd:string |
| http://purl.uniprot.org/citations/22101514 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/22101514 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22101514 |
| http://purl.uniprot.org/citations/22101514 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22101514 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RM25-mappedCitation-22101514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22101514 |
| http://purl.uniprot.org/uniprot/#_E0CZD1-mappedCitation-22101514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22101514 |