| http://purl.uniprot.org/citations/22106694 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22106694 | http://www.w3.org/2000/01/rdf-schema#comment | "HLA-DQA1, -DQB1, and -DRB1 gene polymorphism were analyzed to study type 1 DM susceptibility in Malay patients from Southeast Asia (Malaysia and Singapore). Patients showed significant increases in the occurrence of DQA1*0501 (50.7% vs. 20.4%; RR = 3.97; Pc < 0.01), DQB1*0201 (48% vs. 19.1%; RR = 3.86; Pc < 0.05), and DRB1*0301 (38.7 vs. 6.8%; RR = 8.36; 95% Pc < 0.05). Conversely, significant decreases were noted in the occurrence of DQA1*0601 (14.7% vs. 35.2%; RR = 0.33; Pc = 0.008) and DQB1*0601 (4% vs. 23.5%; RR = 0.16; Pc < 0.05) in type 1 DM patients. Using a logistic regression model, we derived a risk prediction model for type 1 DM in our indigenous Malay population based on the identified HLA genotypes. The RR for type 1 DM increases by a factor of 5.68 for every unit increase in the number of DRB1*0301 allele (P < 0.001), and decreases by a factor of 0.18 per unit increase in the number of DQB1*0601 allele (P < 0.001). After adjusting for these two HLA genotypes, DQA1*0501, DQB1*0201 and DQA1*0601 were not statistically significant as risk predictors. The lower incidence of type 1 DM in the Malay population may be contributed by the genotypic combinations of DR and DQ genes as well as the linkage disequilibria between susceptible and protective alleles."xsd:string |
| http://purl.uniprot.org/citations/22106694 | http://purl.uniprot.org/core/author | "Loh K.C."xsd:string |
| http://purl.uniprot.org/citations/22106694 | http://purl.uniprot.org/core/author | "Khalid B.A."xsd:string |
| http://purl.uniprot.org/citations/22106694 | http://purl.uniprot.org/core/author | "Tin S.K."xsd:string |
| http://purl.uniprot.org/citations/22106694 | http://purl.uniprot.org/core/author | "Fong K.Y."xsd:string |
| http://purl.uniprot.org/citations/22106694 | http://purl.uniprot.org/core/author | "Azmi K.N."xsd:string |
| http://purl.uniprot.org/citations/22106694 | http://purl.uniprot.org/core/author | "Nazaimoon W.M."xsd:string |
| http://purl.uniprot.org/citations/22106694 | http://purl.uniprot.org/core/author | "Rohana A.G."xsd:string |
| http://purl.uniprot.org/citations/22106694 | http://purl.uniprot.org/core/author | "Soh C.H."xsd:string |
| http://purl.uniprot.org/citations/22106694 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22106694 | http://purl.uniprot.org/core/name | "Med J Malaysia"xsd:string |
| http://purl.uniprot.org/citations/22106694 | http://purl.uniprot.org/core/pages | "133-137"xsd:string |
| http://purl.uniprot.org/citations/22106694 | http://purl.uniprot.org/core/title | "HLA-DQ A1, -DQB1 and -DRB1 gene polymorphism--in Malay type 1 diabetes mellitus patients and their use for risk prediction."xsd:string |
| http://purl.uniprot.org/citations/22106694 | http://purl.uniprot.org/core/volume | "66"xsd:string |
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