| http://purl.uniprot.org/citations/22109522 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22109522 | http://www.w3.org/2000/01/rdf-schema#comment | "Cell fusion has a critical role in various developmental processes, immune response, tissue homeostasis and regeneration, and possibly, in cancer. However, the signals that regulate cell fusion remain poorly understood. In a screen for novel targets of Wnt/β-catenin signalling, we identified glial cells missing 1 (GCM1), which encodes a transcription factor that is involved in epigenetic regulation and is critical for the fusion of syncytiotrophoblast (ST) cells. Here we show that β-catenin/BCL9-Like (BCL9L)/T-cell factor 4 (TCF4) signalling directly targets the GCM1/syncytin pathway and thereby regulates the fusion of human choriocarcinoma cells. Furthermore, we show that the GCM1/syncytin-B pathway is significantly downregulated in the placenta of BCL9L-deficient mice and that the fusion and differentiation of ST-II cells are blocked. Our results demonstrate a signal transduction pathway that regulates cell fusion, and may provide intriguing perspectives into the various biological and pathological processes that involve cell fusion."xsd:string |
| http://purl.uniprot.org/citations/22109522 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms1551"xsd:string |
| http://purl.uniprot.org/citations/22109522 | http://purl.uniprot.org/core/author | "Adachi S."xsd:string |
| http://purl.uniprot.org/citations/22109522 | http://purl.uniprot.org/core/author | "Nakamura T."xsd:string |
| http://purl.uniprot.org/citations/22109522 | http://purl.uniprot.org/core/author | "Senda T."xsd:string |
| http://purl.uniprot.org/citations/22109522 | http://purl.uniprot.org/core/author | "Matsuura K."xsd:string |
| http://purl.uniprot.org/citations/22109522 | http://purl.uniprot.org/core/author | "Akiyama T."xsd:string |
| http://purl.uniprot.org/citations/22109522 | http://purl.uniprot.org/core/author | "Morishita Y."xsd:string |
| http://purl.uniprot.org/citations/22109522 | http://purl.uniprot.org/core/author | "Aburatani H."xsd:string |
| http://purl.uniprot.org/citations/22109522 | http://purl.uniprot.org/core/author | "Jigami T."xsd:string |
| http://purl.uniprot.org/citations/22109522 | http://purl.uniprot.org/core/author | "Nonaka A."xsd:string |
| http://purl.uniprot.org/citations/22109522 | http://purl.uniprot.org/core/author | "Taniue K."xsd:string |
| http://purl.uniprot.org/citations/22109522 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22109522 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/22109522 | http://purl.uniprot.org/core/pages | "548"xsd:string |
| http://purl.uniprot.org/citations/22109522 | http://purl.uniprot.org/core/title | "Identification of a link between Wnt/beta-catenin signalling and the cell fusion pathway."xsd:string |
| http://purl.uniprot.org/citations/22109522 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/22109522 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22109522 |
| http://purl.uniprot.org/citations/22109522 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22109522 |
| http://purl.uniprot.org/uniprot/#_A0A0D9SGH8-mappedCitation-22109522 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22109522 |
| http://purl.uniprot.org/uniprot/#_D0EYG5-mappedCitation-22109522 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22109522 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MTL7-mappedCitation-22109522 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22109522 |
| http://purl.uniprot.org/uniprot/#_A0A087WZX0-mappedCitation-22109522 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22109522 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQG4-mappedCitation-22109522 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22109522 |