| http://purl.uniprot.org/citations/22111667 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22111667 | http://www.w3.org/2000/01/rdf-schema#comment | "To explore the role of CD72 in the pathogenesis of immune thrombocytopenia (ITP), we detected CD72, Sema4D, IL-2, IL-4, and IFN-γ mRNA expressions and the levels of plasma Sema4D, IL-2, IL-4, IL-6, and IFN-γ in ITP patients (n = 39) and controls (n = 23). The levels of plasma IL-2, IL-4, and IL-6 were assayed by radioimmunoassay, and the levels of plasma IFN-γ and Sema4D were analyzed by enzyme-linked immunosorbent assay. Sema4D, CD72, IL-2, IFN-γ, and IL-4mRNA expressions were analyzed by real-time quantitative reverse-transcription polymerase chain reaction. The expression of CD72 mRNA in ITP patients (n = 23) with active disease was significantly lower than that in patients in remission (p = 0.029) (n = 16) and controls (p = 0.0296) (n = 23). The IFN-γ/IL-4 mRNA (Th1/Th2) expression in ITP patients with active disease and in remission was significantly higher than that in controls (p = 0.0023, p = 0.0125, respectively). The expression of IL-2 mRNA in ITP patients with active disease was significantly lower than that in patients in remission (p = 0.0418) and controls (p = 0.004). The level of plasma IL-2 in ITP patients with active disease was significantly lower than that in patients in remission (p = 0.0029) and controls (p = 0.0101). The levels of plasma IL-4 in ITP patients with active disease and in remission were significantly higher than that of controls (p = 0.0093, p = 0.0053, respectively). CD72 mRNA expression level might correlate with Sema4D mRNA expression in peripheral blood mononuclear cells and level of plasma IL-2 in active ITP patients (p = 0.024 and p = 0.036). Our findings suggest that CD72 might be involved in the pathophysiological process of the ITP disease by increasing B-cell receptor signals."xsd:string |
| http://purl.uniprot.org/citations/22111667 | http://purl.org/dc/terms/identifier | "doi:10.3109/09537104.2011.633646"xsd:string |
| http://purl.uniprot.org/citations/22111667 | http://purl.uniprot.org/core/author | "Ma L."xsd:string |
| http://purl.uniprot.org/citations/22111667 | http://purl.uniprot.org/core/author | "Zhou H."xsd:string |
| http://purl.uniprot.org/citations/22111667 | http://purl.uniprot.org/core/author | "Li H.Y."xsd:string |
| http://purl.uniprot.org/citations/22111667 | http://purl.uniprot.org/core/author | "Xu J.H."xsd:string |
| http://purl.uniprot.org/citations/22111667 | http://purl.uniprot.org/core/author | "Xue F."xsd:string |
| http://purl.uniprot.org/citations/22111667 | http://purl.uniprot.org/core/author | "Lu S.H."xsd:string |
| http://purl.uniprot.org/citations/22111667 | http://purl.uniprot.org/core/author | "Yang R.C."xsd:string |
| http://purl.uniprot.org/citations/22111667 | http://purl.uniprot.org/core/author | "Zhou Z.P."xsd:string |
| http://purl.uniprot.org/citations/22111667 | http://purl.uniprot.org/core/author | "Zhao Q.J."xsd:string |
| http://purl.uniprot.org/citations/22111667 | http://purl.uniprot.org/core/author | "Qi A.P."xsd:string |
| http://purl.uniprot.org/citations/22111667 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22111667 | http://purl.uniprot.org/core/name | "Platelets"xsd:string |
| http://purl.uniprot.org/citations/22111667 | http://purl.uniprot.org/core/pages | "638-644"xsd:string |
| http://purl.uniprot.org/citations/22111667 | http://purl.uniprot.org/core/title | "CD72 gene expression in immune thrombocytopenia."xsd:string |
| http://purl.uniprot.org/citations/22111667 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/22111667 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22111667 |
| http://purl.uniprot.org/citations/22111667 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22111667 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DG45-mappedCitation-22111667 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22111667 |
| http://purl.uniprot.org/uniprot/#_B7Z9Z2-mappedCitation-22111667 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22111667 |
| http://purl.uniprot.org/uniprot/#_B4DER0-mappedCitation-22111667 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22111667 |
| http://purl.uniprot.org/uniprot/#_Q13169-mappedCitation-22111667 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22111667 |
| http://purl.uniprot.org/uniprot/#_Q71V48-mappedCitation-22111667 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22111667 |