| http://purl.uniprot.org/citations/22111909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22111909 | http://www.w3.org/2000/01/rdf-schema#comment | "Cranial sense organs and a subset of cranial sensory neurons are generated from placodes, thickenings of the ectoderm. Pax3 has been known as a marker for ophthalmic trigeminal placode specification, and also an important regulator of trigeminal placode neuron differentiation. In this study, I show that Pax6 is initially expressed in the preplacodal region at the level of ophthalmic trigeminal placode, and that this expression gradually regresses in a medial-to-lateral direction as Pax3 expression expands in the same direction. Misexpression studies revealed that Pax6 represses Pax3 expression indirectly as a transcriptional activator in a cell-autonomous manner. Pax3-misexpression represses Pax6 expression in an indirect fashion, suggesting that unknown factor(s) downstream of Pax3 may repress Pax6 expression, and thereby allow an expansion of Pax3-positive ophthalmic trigeminal placode region. These results indicate that the mutual repression between Pax3 and Pax6 has important roles in the specification and the positioning of the ophthalmic trigeminal placode."xsd:string |
| http://purl.uniprot.org/citations/22111909 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1440-169x.2011.01311.x"xsd:string |
| http://purl.uniprot.org/citations/22111909 | http://purl.uniprot.org/core/author | "Wakamatsu Y."xsd:string |
| http://purl.uniprot.org/citations/22111909 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22111909 | http://purl.uniprot.org/core/name | "Dev Growth Differ"xsd:string |
| http://purl.uniprot.org/citations/22111909 | http://purl.uniprot.org/core/pages | "994-1003"xsd:string |
| http://purl.uniprot.org/citations/22111909 | http://purl.uniprot.org/core/title | "Mutual repression between Pax3 and Pax6 is involved in the positioning of ophthalmic trigeminal placode in avian embryo."xsd:string |
| http://purl.uniprot.org/citations/22111909 | http://purl.uniprot.org/core/volume | "53"xsd:string |
| http://purl.uniprot.org/citations/22111909 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22111909 |
| http://purl.uniprot.org/citations/22111909 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22111909 |
| http://purl.uniprot.org/uniprot/#_O42348-mappedCitation-22111909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22111909 |
| http://purl.uniprot.org/uniprot/#_P47237-mappedCitation-22111909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22111909 |
| http://purl.uniprot.org/uniprot/#_Q8QGS3-mappedCitation-22111909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22111909 |
| http://purl.uniprot.org/uniprot/P47237 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22111909 |
| http://purl.uniprot.org/uniprot/Q8QGS3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22111909 |
| http://purl.uniprot.org/uniprot/O42348 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22111909 |