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| http://purl.uniprot.org/citations/22115574 | http://www.w3.org/2000/01/rdf-schema#comment | "Wee1 protein kinase represses CDK1 required for G(2)/M transition. The mouse wee1 promoter contains multiple CACCC-boxes between -306 and +1 that can bind to Krüppel-like factor 3 (KLF3) transcriptional repressor. We found that increasing amounts of intracellular KLF3 decreased the amount of wee1 mRNA. A promoter reporter assay demonstrated that wee1 promoter activity was repressed by KLF3 overexpression. Elimination of the first and fourth CACCC-boxes suppressed KLF3-governed transcriptional repression. A gel-shift assay demonstrated that KLF3 binds to the first, third, and fourth CACCC-boxes with various strengths. Moreover, KLF3 was suggested to interact with the wee1 regulatory region in a physiological condition. Therefore, we concluded that KLF3 is a transcriptional repressor for wee1 gene. In a previous study, we demonstrated that TBP-like protein (TLP) inhibits wee1 promoter function. In this study, we found that the chromosomal wee1 gene is also down-regulated by KLF3. Since KLF3-repressed wee1 promoter function was further inhibited by TLP overexpression regardless of the inhibition degree of KLF3, we propose that TLP and KLF3 repress wee1 promoter independently."xsd:string |
| http://purl.uniprot.org/citations/22115574 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.gene.2011.11.016"xsd:string |
| http://purl.uniprot.org/citations/22115574 | http://purl.uniprot.org/core/author | "Suzuki H."xsd:string |
| http://purl.uniprot.org/citations/22115574 | http://purl.uniprot.org/core/author | "Kitamura T."xsd:string |
| http://purl.uniprot.org/citations/22115574 | http://purl.uniprot.org/core/author | "Tamura T.A."xsd:string |
| http://purl.uniprot.org/citations/22115574 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22115574 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/22115574 | http://purl.uniprot.org/core/pages | "361-367"xsd:string |
| http://purl.uniprot.org/citations/22115574 | http://purl.uniprot.org/core/title | "Mouse Wee1 gene is repressed by Kruppel-like factor 3 (KLF3) via interaction with multiple upstream elements."xsd:string |
| http://purl.uniprot.org/citations/22115574 | http://purl.uniprot.org/core/volume | "492"xsd:string |
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