| http://purl.uniprot.org/citations/2211670 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2211670 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2211670 | http://www.w3.org/2000/01/rdf-schema#comment | "Treatment of a variety of cells and tissues with 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of protein kinase C (PKC) results in the inhibition of receptor-coupled inositol phospholipid-specific phospholipase C (PLC) activity. To determine whether or not the targets of TPA-activated PKC include one or more isozymes of PLC, studies were carried out with PC12, C6Bu1, and NIH 3T3 cells, which contain at least three PLC isozymes, PLC-beta, PLC-gamma, and PLC-delta. Treatment of the cells with TPA stimulated the phosphorylation of serine residues in PLC-beta, but the phosphorylation state of PLC-gamma and PLC-delta was not changed significantly. Phosphorylation of bovine brain PLC-beta by PKC in vitro resulted in a stoichiometric incorporation of phosphate at serine 887, without any concomitant effect on PLC-beta activity. We propose, therefore, that rather than having a direct effect on enzyme activity, the phosphorylation of PLC-beta by PKC may alter its interaction with a putative guanine nucleotide-binding regulatory protein and thereby prevent its activation."xsd:string |
| http://purl.uniprot.org/citations/2211670 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(18)38254-1"xsd:string |
| http://purl.uniprot.org/citations/2211670 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(18)38254-1"xsd:string |
| http://purl.uniprot.org/citations/2211670 | http://purl.uniprot.org/core/author | "Rhee S.G."xsd:string |
| http://purl.uniprot.org/citations/2211670 | http://purl.uniprot.org/core/author | "Rhee S.G."xsd:string |
| http://purl.uniprot.org/citations/2211670 | http://purl.uniprot.org/core/author | "Carpenter G."xsd:string |
| http://purl.uniprot.org/citations/2211670 | http://purl.uniprot.org/core/author | "Carpenter G."xsd:string |
| http://purl.uniprot.org/citations/2211670 | http://purl.uniprot.org/core/author | "Ryu S.H."xsd:string |
| http://purl.uniprot.org/citations/2211670 | http://purl.uniprot.org/core/author | "Ryu S.H."xsd:string |
| http://purl.uniprot.org/citations/2211670 | http://purl.uniprot.org/core/author | "Wahl M.I."xsd:string |
| http://purl.uniprot.org/citations/2211670 | http://purl.uniprot.org/core/author | "Wahl M.I."xsd:string |
| http://purl.uniprot.org/citations/2211670 | http://purl.uniprot.org/core/author | "Kim U.H."xsd:string |
| http://purl.uniprot.org/citations/2211670 | http://purl.uniprot.org/core/author | "Kim U.H."xsd:string |
| http://purl.uniprot.org/citations/2211670 | http://purl.uniprot.org/core/author | "Huang K.P."xsd:string |
| http://purl.uniprot.org/citations/2211670 | http://purl.uniprot.org/core/author | "Huang K.P."xsd:string |
| http://purl.uniprot.org/citations/2211670 | http://purl.uniprot.org/core/author | "Brown A.B."xsd:string |
| http://purl.uniprot.org/citations/2211670 | http://purl.uniprot.org/core/author | "Brown A.B."xsd:string |
| http://purl.uniprot.org/citations/2211670 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2211670 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2211670 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/2211670 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/2211670 | http://purl.uniprot.org/core/pages | "17941-17945"xsd:string |
| http://purl.uniprot.org/citations/2211670 | http://purl.uniprot.org/core/pages | "17941-17945"xsd:string |