| http://purl.uniprot.org/citations/22118460 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22118460 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22118460 | http://www.w3.org/2000/01/rdf-schema#comment | "The DDB1-CUL4-RBX1 (CRL4) ubiquitin ligase family regulates a diverse set of cellular pathways through dedicated substrate receptors (DCAFs). The DCAF DDB2 detects UV-induced pyrimidine dimers in the genome and facilitates nucleotide excision repair. We provide the molecular basis for DDB2 receptor-mediated cyclobutane pyrimidine dimer recognition in chromatin. The structures of the fully assembled DDB1-DDB2-CUL4A/B-RBX1 (CRL4(DDB2)) ligases reveal that the mobility of the ligase arm creates a defined ubiquitination zone around the damage, which precludes direct ligase activation by DNA lesions. Instead, the COP9 signalosome (CSN) mediates the CRL4(DDB2) inhibition in a CSN5 independent, nonenzymatic, fashion. In turn, CSN inhibition is relieved upon DNA damage binding to the DDB2 module within CSN-CRL4(DDB2). The Cockayne syndrome A DCAF complex crystal structure shows that CRL4(DCAF(WD40)) ligases share common architectural features. Our data support a general mechanism of ligase activation, which is induced by CSN displacement from CRL4(DCAF) on substrate binding to the DCAF."xsd:string |
| http://purl.uniprot.org/citations/22118460 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2011.10.035"xsd:string |
| http://purl.uniprot.org/citations/22118460 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2011.10.035"xsd:string |
| http://purl.uniprot.org/citations/22118460 | http://purl.uniprot.org/core/author | "Hanaoka F."xsd:string |
| http://purl.uniprot.org/citations/22118460 | http://purl.uniprot.org/core/author | "Hanaoka F."xsd:string |
| http://purl.uniprot.org/citations/22118460 | http://purl.uniprot.org/core/author | "Iwai S."xsd:string |
| http://purl.uniprot.org/citations/22118460 | http://purl.uniprot.org/core/author | "Iwai S."xsd:string |
| http://purl.uniprot.org/citations/22118460 | http://purl.uniprot.org/core/author | "Lingaraju G.M."xsd:string |
| http://purl.uniprot.org/citations/22118460 | http://purl.uniprot.org/core/author | "Lingaraju G.M."xsd:string |
| http://purl.uniprot.org/citations/22118460 | http://purl.uniprot.org/core/author | "Gut H."xsd:string |
| http://purl.uniprot.org/citations/22118460 | http://purl.uniprot.org/core/author | "Gut H."xsd:string |
| http://purl.uniprot.org/citations/22118460 | http://purl.uniprot.org/core/author | "Yasuda T."xsd:string |
| http://purl.uniprot.org/citations/22118460 | http://purl.uniprot.org/core/author | "Yasuda T."xsd:string |
| http://purl.uniprot.org/citations/22118460 | http://purl.uniprot.org/core/author | "Matsumoto S."xsd:string |
| http://purl.uniprot.org/citations/22118460 | http://purl.uniprot.org/core/author | "Matsumoto S."xsd:string |
| http://purl.uniprot.org/citations/22118460 | http://purl.uniprot.org/core/author | "Scrima A."xsd:string |
| http://purl.uniprot.org/citations/22118460 | http://purl.uniprot.org/core/author | "Scrima A."xsd:string |
| http://purl.uniprot.org/citations/22118460 | http://purl.uniprot.org/core/author | "Wakasugi M."xsd:string |
| http://purl.uniprot.org/citations/22118460 | http://purl.uniprot.org/core/author | "Wakasugi M."xsd:string |
| http://purl.uniprot.org/citations/22118460 | http://purl.uniprot.org/core/author | "Thoma N.H."xsd:string |
| http://purl.uniprot.org/citations/22118460 | http://purl.uniprot.org/core/author | "Thoma N.H."xsd:string |
| http://purl.uniprot.org/citations/22118460 | http://purl.uniprot.org/core/author | "Bohm K."xsd:string |
| http://purl.uniprot.org/citations/22118460 | http://purl.uniprot.org/core/author | "Bohm K."xsd:string |