| http://purl.uniprot.org/citations/22119193 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22119193 | http://www.w3.org/2000/01/rdf-schema#comment | "Calponin-3 is an actin-interacting protein and is expressed in the brain. Our previous microarray scan has found an up-regulation of calponin-3 gene CNN3 in the temporal lobe of patients with drug-resistant epilepsy. Here we investigated in epileptic patients the changes of brain and cerebrospinal fluid (CSF) calponin-3 expressions, and assessed calponin-3 expression pattern in a rat model of pilocarpine-induced epilepsy. We showed that in the temporal neocortices of 30 patients with drug-resistant epilepsy, both mRNA and protein level of calponin-3 were significantly increased. In addition, the augmentation of CSF calponin-3 from 126 epileptic patients was closely correlated with disease duration. Moreover, in the cortices of temporal lobes of pilocarpine-treated rats, calponin-3 increased along with the time and maintained at significant high levels for up to 2 months, while the up-regulation of hippocampal calponin-3 only occurred at 24h and 1 week. The elevated calponin-3 suggests that deregulation of actin filament dynamics in axonal and dendritic outgrowth and synaptic rearrangement may contribute to pathophysiology of epilepsy."xsd:string |
| http://purl.uniprot.org/citations/22119193 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.expneurol.2011.11.014"xsd:string |
| http://purl.uniprot.org/citations/22119193 | http://purl.uniprot.org/core/author | "Chen G."xsd:string |
| http://purl.uniprot.org/citations/22119193 | http://purl.uniprot.org/core/author | "Han Y."xsd:string |
| http://purl.uniprot.org/citations/22119193 | http://purl.uniprot.org/core/author | "Luo J."xsd:string |
| http://purl.uniprot.org/citations/22119193 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/22119193 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/22119193 | http://purl.uniprot.org/core/author | "Yin H."xsd:string |
| http://purl.uniprot.org/citations/22119193 | http://purl.uniprot.org/core/author | "Zhu Q."xsd:string |
| http://purl.uniprot.org/citations/22119193 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22119193 | http://purl.uniprot.org/core/name | "Exp Neurol"xsd:string |
| http://purl.uniprot.org/citations/22119193 | http://purl.uniprot.org/core/pages | "430-437"xsd:string |
| http://purl.uniprot.org/citations/22119193 | http://purl.uniprot.org/core/title | "Increased expression of calponin-3 in epileptic patients and experimental rats."xsd:string |
| http://purl.uniprot.org/citations/22119193 | http://purl.uniprot.org/core/volume | "233"xsd:string |
| http://purl.uniprot.org/citations/22119193 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22119193 |
| http://purl.uniprot.org/citations/22119193 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22119193 |
| http://purl.uniprot.org/uniprot/#_Q15417-mappedCitation-22119193 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22119193 |
| http://purl.uniprot.org/uniprot/#_Q9BWY6-mappedCitation-22119193 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22119193 |
| http://purl.uniprot.org/uniprot/Q15417 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22119193 |
| http://purl.uniprot.org/uniprot/Q9BWY6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22119193 |