| http://purl.uniprot.org/citations/22119730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22119730 | http://www.w3.org/2000/01/rdf-schema#comment | "Several neurodegenerative disorders are characterized by the accumulation of proteinaceous inclusions in the central nervous system. These inclusions are frequently composed of a mixture of aggregation-prone proteins. Here, we used a bimolecular fluorescence complementation assay to study the initial steps of the co-aggregation of huntingtin (Htt) and α-synuclein (α-syn), two aggregation-prone proteins involved in Huntington's disease (HD) and Parkinson's disease (PD), respectively. We found that Htt (exon 1) oligomerized with α-syn and sequestered it in the cytosol. In turn, α-syn increased the number of cells displaying aggregates, decreased the number of aggregates per cell and increased the average size of the aggregates. Our results support the idea that co-aggregation of aggregation-prone proteins can contribute to the histopathology of neurodegenerative disorders."xsd:string |
| http://purl.uniprot.org/citations/22119730 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2011.11.019"xsd:string |
| http://purl.uniprot.org/citations/22119730 | http://purl.uniprot.org/core/author | "Outeiro T.F."xsd:string |
| http://purl.uniprot.org/citations/22119730 | http://purl.uniprot.org/core/author | "Herrera F."xsd:string |
| http://purl.uniprot.org/citations/22119730 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22119730 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/22119730 | http://purl.uniprot.org/core/pages | "7-12"xsd:string |
| http://purl.uniprot.org/citations/22119730 | http://purl.uniprot.org/core/title | "alpha-Synuclein modifies huntingtin aggregation in living cells."xsd:string |
| http://purl.uniprot.org/citations/22119730 | http://purl.uniprot.org/core/volume | "586"xsd:string |
| http://purl.uniprot.org/citations/22119730 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22119730 |
| http://purl.uniprot.org/citations/22119730 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22119730 |
| http://purl.uniprot.org/uniprot/P42858#attribution-B508C0D68871D3E2BE8E7FDE1533D124 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22119730 |
| http://purl.uniprot.org/uniprot/#_A0A2Z5HU10-mappedCitation-22119730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22119730 |
| http://purl.uniprot.org/uniprot/#_A8K3C9-mappedCitation-22119730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22119730 |
| http://purl.uniprot.org/uniprot/#_D2CTD2-mappedCitation-22119730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22119730 |
| http://purl.uniprot.org/uniprot/#_D2CTD4-mappedCitation-22119730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22119730 |
| http://purl.uniprot.org/uniprot/#_D2CTD5-mappedCitation-22119730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22119730 |
| http://purl.uniprot.org/uniprot/#_D2CTD6-mappedCitation-22119730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22119730 |
| http://purl.uniprot.org/uniprot/#_D2CTD7-mappedCitation-22119730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22119730 |
| http://purl.uniprot.org/uniprot/#_D2CTD8-mappedCitation-22119730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22119730 |
| http://purl.uniprot.org/uniprot/#_D2CTD9-mappedCitation-22119730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22119730 |
| http://purl.uniprot.org/uniprot/#_D2CTE1-mappedCitation-22119730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22119730 |
| http://purl.uniprot.org/uniprot/#_D2CTE3-mappedCitation-22119730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22119730 |
| http://purl.uniprot.org/uniprot/#_D2CTE5-mappedCitation-22119730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22119730 |