| http://purl.uniprot.org/citations/22120631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22120631 | http://www.w3.org/2000/01/rdf-schema#comment | "The ubiquitin E3 ligase CUL4A plays important roles in diverse cellular processes including carcinogenesis and proliferation. It has been reported that the expression of CUL4A can be induced by hypoxic-ischemic injury. However, the effect of elevated expression of CUL4A on hypoxia-reoxygenation injury is currently unclear. In this study, human CUL4A (hCUL4A) was expressed in rat pheochromocytoma (PC12) cells using adenoviral vector-mediated gene transfer, and the effects of hCUL4A expression on hypoxia-reoxygenation injury were investigated. In PC12 cells subjected to hypoxia and reoxygenation, we found that hCUL4A suppresses apoptosis and DNA damage by regulating apoptosis-related proteins and cell cycle regulators (Bcl-2, caspase-3, p53 and p27); consequently, hCUL4A promotes cell survival. Taken together, our results reveal the beneficial effects of hCUL4A in PC12 cells upon hypoxia-reoxygenation injury."xsd:string |
| http://purl.uniprot.org/citations/22120631 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2011.11.054"xsd:string |
| http://purl.uniprot.org/citations/22120631 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/22120631 | http://purl.uniprot.org/core/author | "Xiao L."xsd:string |
| http://purl.uniprot.org/citations/22120631 | http://purl.uniprot.org/core/author | "Zhang L.Y."xsd:string |
| http://purl.uniprot.org/citations/22120631 | http://purl.uniprot.org/core/author | "Zhang J.X."xsd:string |
| http://purl.uniprot.org/citations/22120631 | http://purl.uniprot.org/core/author | "Liu X.P."xsd:string |
| http://purl.uniprot.org/citations/22120631 | http://purl.uniprot.org/core/author | "Tan C."xsd:string |
| http://purl.uniprot.org/citations/22120631 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22120631 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/22120631 | http://purl.uniprot.org/core/pages | "403-408"xsd:string |
| http://purl.uniprot.org/citations/22120631 | http://purl.uniprot.org/core/title | "Overexpression of the human ubiquitin E3 ligase CUL4A alleviates hypoxia-reoxygenation injury in pheochromocytoma (PC12) cells."xsd:string |
| http://purl.uniprot.org/citations/22120631 | http://purl.uniprot.org/core/volume | "416"xsd:string |
| http://purl.uniprot.org/citations/22120631 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22120631 |
| http://purl.uniprot.org/citations/22120631 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22120631 |
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