| http://purl.uniprot.org/citations/22124122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22124122 | http://www.w3.org/2000/01/rdf-schema#comment | "Follicular dendritic cells (FDCs) protect germinal center (GC) B cells from rapid apoptosis to allow their survival and maturation. In this article, we show that FDCs normally produce and secrete Wnt5a to protect GC B cells. Wnt5a production is upregulated by polyI:C. Purified Wnt5a protects GC B cells from apoptosis in a dose-dependent manner. GC B cells are protected by FDC coculture or conditioned medium, and the protection is inhibited significantly by anti-Wnt5a Ab, suggesting a major role of Wnt5a in the FDC-mediated GC B cell protection. A calcium chelator BAPTA-AM blocks the Wnt5a-mediated GC B cell protection, implying a role of Wnt/Ca(2+) signaling in the GC B cell survival. Wnt5a and calcium ionophore activate NFATc1, NFATc2, NF-κB, and B cell lymphoma 6 (BCL-6) promptly and upregulate CD40 expression in GC B and Ramos cells, whereas p53 and JNK are not upregulated or activated. Cyclosporine A inhibits the Wnt5a and calcium-induced activation of NF-κB and BCL-6 in Ramos cells, supporting a role of β-catenin-independent Wnt/Ca(2+)/NFAT/NF-κB-BCL-6 signaling. Our data support that Wnt5a is a novel survival factor for GC B cells and might be a potential target for the regulation of B cell immunity."xsd:string |
| http://purl.uniprot.org/citations/22124122 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1102297"xsd:string |
| http://purl.uniprot.org/citations/22124122 | http://purl.uniprot.org/core/author | "Chang W."xsd:string |
| http://purl.uniprot.org/citations/22124122 | http://purl.uniprot.org/core/author | "Kim J."xsd:string |
| http://purl.uniprot.org/citations/22124122 | http://purl.uniprot.org/core/author | "Park C.S."xsd:string |
| http://purl.uniprot.org/citations/22124122 | http://purl.uniprot.org/core/author | "Kim D.W."xsd:string |
| http://purl.uniprot.org/citations/22124122 | http://purl.uniprot.org/core/author | "Choe J."xsd:string |
| http://purl.uniprot.org/citations/22124122 | http://purl.uniprot.org/core/author | "Song K."xsd:string |
| http://purl.uniprot.org/citations/22124122 | http://purl.uniprot.org/core/author | "Kim J.'"xsd:string |
| http://purl.uniprot.org/citations/22124122 | http://purl.uniprot.org/core/author | "Lee I."xsd:string |
| http://purl.uniprot.org/citations/22124122 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22124122 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/22124122 | http://purl.uniprot.org/core/pages | "182-189"xsd:string |
| http://purl.uniprot.org/citations/22124122 | http://purl.uniprot.org/core/title | "Wnt5a is secreted by follicular dendritic cells to protect germinal center B cells via Wnt/Ca2+/NFAT/NF-kappaB-B cell lymphoma 6 signaling."xsd:string |
| http://purl.uniprot.org/citations/22124122 | http://purl.uniprot.org/core/volume | "188"xsd:string |
| http://purl.uniprot.org/citations/22124122 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22124122 |
| http://purl.uniprot.org/citations/22124122 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22124122 |
| http://purl.uniprot.org/uniprot/#_A0A384N611-mappedCitation-22124122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22124122 |
| http://purl.uniprot.org/uniprot/#_A0FKN4-mappedCitation-22124122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22124122 |
| http://purl.uniprot.org/uniprot/#_B3KQX9-mappedCitation-22124122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22124122 |
| http://purl.uniprot.org/uniprot/#_P22725-mappedCitation-22124122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22124122 |
| http://purl.uniprot.org/uniprot/#_P41183-mappedCitation-22124122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22124122 |
| http://purl.uniprot.org/uniprot/#_P41221-mappedCitation-22124122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22124122 |
| http://purl.uniprot.org/uniprot/#_Q8CB25-mappedCitation-22124122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22124122 |