| http://purl.uniprot.org/citations/22131337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22131337 | http://www.w3.org/2000/01/rdf-schema#comment | "Virus infection induces the MAVS-TNFR-associated factor (TRAF) 3 signaling axis on mitochondria. It remains to elucidate the corresponding regulatory processes. In this study, we identify UXT-V1 as a novel TRAF3-binding protein. UXT-V1 is critical for the virus-induced activation of NF-κB and IFN regulatory factor 3. Reduction of UXT-V1 impairs the induction of IFN-β and attenuates the host antiviral responses. The N-terminal TRAF-binding motif of UXT-V1 binds to the C-terminal TRAF domain of TRAF3, thus facilitating the interaction between TRAF3 and MAVS. Notably, TRAF3 and TNFR-associated death domain protein are recruited onto mitochondria upon virus infection. These translocations are blocked when knocking down UXT-V1. Thus, UXT-V1 represents a novel integral component of the MAVS signalosome on mitochondria, mediating the innate antiviral signal transduction."xsd:string |
| http://purl.uniprot.org/citations/22131337 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1102079"xsd:string |
| http://purl.uniprot.org/citations/22131337 | http://purl.uniprot.org/core/author | "Huang Y."xsd:string |
| http://purl.uniprot.org/citations/22131337 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/22131337 | http://purl.uniprot.org/core/author | "Lou X."xsd:string |
| http://purl.uniprot.org/citations/22131337 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/22131337 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/22131337 | http://purl.uniprot.org/core/author | "Ge R."xsd:string |
| http://purl.uniprot.org/citations/22131337 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22131337 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/22131337 | http://purl.uniprot.org/core/pages | "358-366"xsd:string |
| http://purl.uniprot.org/citations/22131337 | http://purl.uniprot.org/core/title | "UXT-V1 facilitates the formation of MAVS antiviral signalosome on mitochondria."xsd:string |
| http://purl.uniprot.org/citations/22131337 | http://purl.uniprot.org/core/volume | "188"xsd:string |
| http://purl.uniprot.org/citations/22131337 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22131337 |
| http://purl.uniprot.org/citations/22131337 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22131337 |
| http://purl.uniprot.org/uniprot/#_Q8K2X4-mappedCitation-22131337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22131337 |
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