| http://purl.uniprot.org/citations/22139301 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22139301 | http://www.w3.org/2000/01/rdf-schema#comment | "Retinoblastoma binding protein 6 (RBBP6) is a nuclear protein, previously implicated in the regulation of cell cycle and apoptosis. The human RBBP6 gene codes for three protein isoforms and isoform 3 consists of the domain with no name domain only whilst the other two isoforms, 1 and 2 comprise of additional zinc, RING, retinoblastoma and p53 binding domains. In this study, the localization of RBBP6 using RBBP6 variant 3 mRNA-specific probe was performed to investigate the expression levels of the gene in different tumours and find a link between RBBP6 and human carcinogenesis. Using FISH, real-time PCR and Western blotting analysis our results show that RBBP6 isoform 3 is down-regulated in human cancers. RBBP6 isoform 3 knock-down resulted in reduced G2/M cell cycle arrest whilst its over-expression resulted in increased G2/M cell cycle arrest using propidium iodide DNA staining. The results further demonstrate that the RBBP6 isoform 3 may be the cell cycle regulator and involved in mitotic apoptosis not the isoform 1 as previously reported for mice. In conclusion, these findings suggest that RBBP6 isoform 3 is a cell cycle regulator and may be de-regulated in carcinogenesis."xsd:string |
| http://purl.uniprot.org/citations/22139301 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11010-011-1150-5"xsd:string |
| http://purl.uniprot.org/citations/22139301 | http://purl.uniprot.org/core/author | "Meyer M."xsd:string |
| http://purl.uniprot.org/citations/22139301 | http://purl.uniprot.org/core/author | "Rees J."xsd:string |
| http://purl.uniprot.org/citations/22139301 | http://purl.uniprot.org/core/author | "Skepu A."xsd:string |
| http://purl.uniprot.org/citations/22139301 | http://purl.uniprot.org/core/author | "Hosie M."xsd:string |
| http://purl.uniprot.org/citations/22139301 | http://purl.uniprot.org/core/author | "Dlamini Z."xsd:string |
| http://purl.uniprot.org/citations/22139301 | http://purl.uniprot.org/core/author | "Mbita Z."xsd:string |
| http://purl.uniprot.org/citations/22139301 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22139301 | http://purl.uniprot.org/core/name | "Mol Cell Biochem"xsd:string |
| http://purl.uniprot.org/citations/22139301 | http://purl.uniprot.org/core/pages | "249-262"xsd:string |
| http://purl.uniprot.org/citations/22139301 | http://purl.uniprot.org/core/title | "De-regulation of the RBBP6 isoform 3/DWNN in human cancers."xsd:string |
| http://purl.uniprot.org/citations/22139301 | http://purl.uniprot.org/core/volume | "362"xsd:string |
| http://purl.uniprot.org/citations/22139301 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22139301 |
| http://purl.uniprot.org/citations/22139301 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22139301 |
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