| http://purl.uniprot.org/citations/22142223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22142223 | http://www.w3.org/2000/01/rdf-schema#comment | "Development of the nervous system is finely regulated by consecutive expression of cell-specific transcription factors. Here we show that Helios, a member of the Ikaros transcription factor family, is expressed in ectodermal and neuroectodermal-derived tissues. During embryonic development, Helios is expressed by several brain structures including the lateral ganglionic eminence (LGE, the striatal anlage); the cingulated, insular and retrosplenial cortex; the hippocampus; and the accessory olfactory bulb. Moreover, Helios is also expressed by Purkinje neurons during postnatal cerebellar development. Within the LGE, Helios expression follows a dynamic spatio-temporal pattern starting at embryonic stages (E14.5), peaking at E18.5, and completely disappearing during postnatal development. Helios is expressed by a small population of nestin-positive neural progenitor cells located in the subventricular zone as well as by a larger population of immature neurons distributed throughout the mantle zone. In the later, Helios is preferentially expressed in the matrix compartment, where it colocalizes with Bcl11b and Foxp1, well-known markers of striatal projection neurons. In addition, we observed that Helios expression is not detected in Dlx1/2 and Gsx2 null mutants, while its expression is maintained in Ascl1 mutants. These findings allow us to introduce a new transcription factor in the cascade of events that take part of striatal development postulating the existence of at least 4 different neural progenitors in the LGE. An Ascl1-independent but Gsx2-& Dlx1/2-dependent precursor will express Helios defining a new lineage for a subset of matrix striatal neurons."xsd:string |
| http://purl.uniprot.org/citations/22142223 | http://purl.org/dc/terms/identifier | "doi:10.1089/scd.2011.0607"xsd:string |
| http://purl.uniprot.org/citations/22142223 | http://purl.uniprot.org/core/author | "Wang B."xsd:string |
| http://purl.uniprot.org/citations/22142223 | http://purl.uniprot.org/core/author | "Chan S."xsd:string |
| http://purl.uniprot.org/citations/22142223 | http://purl.uniprot.org/core/author | "Campbell K."xsd:string |
| http://purl.uniprot.org/citations/22142223 | http://purl.uniprot.org/core/author | "Martinez S."xsd:string |
| http://purl.uniprot.org/citations/22142223 | http://purl.uniprot.org/core/author | "Esgleas M."xsd:string |
| http://purl.uniprot.org/citations/22142223 | http://purl.uniprot.org/core/author | "Urban N."xsd:string |
| http://purl.uniprot.org/citations/22142223 | http://purl.uniprot.org/core/author | "Georgopoulos K."xsd:string |
| http://purl.uniprot.org/citations/22142223 | http://purl.uniprot.org/core/author | "Rubenstein J.L."xsd:string |
| http://purl.uniprot.org/citations/22142223 | http://purl.uniprot.org/core/author | "Kastner P."xsd:string |
| http://purl.uniprot.org/citations/22142223 | http://purl.uniprot.org/core/author | "Canals J.M."xsd:string |
| http://purl.uniprot.org/citations/22142223 | http://purl.uniprot.org/core/author | "Crespo E."xsd:string |
| http://purl.uniprot.org/citations/22142223 | http://purl.uniprot.org/core/author | "Alberch J."xsd:string |
| http://purl.uniprot.org/citations/22142223 | http://purl.uniprot.org/core/author | "Vicario-Abejon C."xsd:string |
| http://purl.uniprot.org/citations/22142223 | http://purl.uniprot.org/core/author | "Martin-Ibanez R."xsd:string |
| http://purl.uniprot.org/citations/22142223 | http://purl.uniprot.org/core/author | "Waclaw R."xsd:string |
| http://purl.uniprot.org/citations/22142223 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22142223 | http://purl.uniprot.org/core/name | "Stem Cells Dev"xsd:string |
| http://purl.uniprot.org/citations/22142223 | http://purl.uniprot.org/core/pages | "2239-2251"xsd:string |
| http://purl.uniprot.org/citations/22142223 | http://purl.uniprot.org/core/title | "Helios transcription factor expression depends on Gsx2 and Dlx1&2 function in developing striatal matrix neurons."xsd:string |
| http://purl.uniprot.org/citations/22142223 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/22142223 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22142223 |
| http://purl.uniprot.org/citations/22142223 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22142223 |