| http://purl.uniprot.org/citations/22153509 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22153509 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22153509 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-5 (IL-5) is the key mediator for the function of eosinophil granulocytes, whose deregulation is characteristic of hypereosinophilic diseases and presumably contributes to allergic asthma. IL-5 signaling involves two transmembrane receptors, IL-5Rα and the common β chain, which upon formation of the ternary complex activate the JAK/STAT signaling cascade. To investigate the mechanism underlying ligand-receptor recognition, we determined the structure of IL-5 bound to the extracellular domain of IL-5Rα. IL-5 makes contact with all three fibronectin III-like domains of IL-5Rα, with the receptor architecture resembling a wrench. Mutagenesis data provide evidence that this wrench-like architecture is likely preformed. The structure demonstrates that for steric reasons, homodimeric IL-5 can bind only one receptor molecule, even though two equivalent receptor-binding sites exist. In regard to strong efforts being made to develop IL-5 antagonists for treating asthma and hypereosinophilic diseases, the advances in molecular understanding provided by this structure are of greatest value."xsd:string |
| http://purl.uniprot.org/citations/22153509 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2011.08.015"xsd:string |
| http://purl.uniprot.org/citations/22153509 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2011.08.015"xsd:string |
| http://purl.uniprot.org/citations/22153509 | http://purl.uniprot.org/core/author | "Schmitz W."xsd:string |
| http://purl.uniprot.org/citations/22153509 | http://purl.uniprot.org/core/author | "Schmitz W."xsd:string |
| http://purl.uniprot.org/citations/22153509 | http://purl.uniprot.org/core/author | "Sebald W."xsd:string |
| http://purl.uniprot.org/citations/22153509 | http://purl.uniprot.org/core/author | "Sebald W."xsd:string |
| http://purl.uniprot.org/citations/22153509 | http://purl.uniprot.org/core/author | "Kotzsch A."xsd:string |
| http://purl.uniprot.org/citations/22153509 | http://purl.uniprot.org/core/author | "Kotzsch A."xsd:string |
| http://purl.uniprot.org/citations/22153509 | http://purl.uniprot.org/core/author | "Mueller T.D."xsd:string |
| http://purl.uniprot.org/citations/22153509 | http://purl.uniprot.org/core/author | "Mueller T.D."xsd:string |
| http://purl.uniprot.org/citations/22153509 | http://purl.uniprot.org/core/author | "Nickel J."xsd:string |
| http://purl.uniprot.org/citations/22153509 | http://purl.uniprot.org/core/author | "Nickel J."xsd:string |
| http://purl.uniprot.org/citations/22153509 | http://purl.uniprot.org/core/author | "Saremba S."xsd:string |
| http://purl.uniprot.org/citations/22153509 | http://purl.uniprot.org/core/author | "Saremba S."xsd:string |
| http://purl.uniprot.org/citations/22153509 | http://purl.uniprot.org/core/author | "Patino E."xsd:string |
| http://purl.uniprot.org/citations/22153509 | http://purl.uniprot.org/core/author | "Patino E."xsd:string |
| http://purl.uniprot.org/citations/22153509 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22153509 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22153509 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/22153509 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/22153509 | http://purl.uniprot.org/core/pages | "1864-1875"xsd:string |
| http://purl.uniprot.org/citations/22153509 | http://purl.uniprot.org/core/pages | "1864-1875"xsd:string |