| http://purl.uniprot.org/citations/22156595 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22156595 | http://www.w3.org/2000/01/rdf-schema#comment | "Bleeding disorders and thrombotic complications constitute a major cause of death and disability worldwide. Although it is known that the complement and coagulation systems interact, no studies have investigated the specific role or mechanisms of lectin-mediated coagulation in vivo. FeCl(3) treatment resulted in intra-arterial occlusive thrombogenesis within 10 min in wild-type (WT) and C2/factor B-null mice. In contrast, mannose-binding lectin (MBL)-null and MBL-associated serine protease (MASP)-1/-3 knockout (KO) mice had significantly decreased FeCl(3)-induced thrombogenesis. Reconstitution with recombinant human (rh) MBL restored FeCl(3)-induced thrombogenesis in MBL-null mice to levels comparable to WT mice, suggesting a significant role of the MBL/MASP complex for in vivo coagulation. Additionally, whole blood aggregation demonstrated increased MBL/MASP complex-dependent platelet aggregation. In vitro, MBL/MASP complexes were captured on mannan-coated plates, and cleavage of a chromogenic thrombin substrate (S2238) was measured. We observed no significant differences in S2238 cleavage between WT, C2/factor B-null, MBL-A(-/-), or MBL-C(-/-) sera; however, MBL-null or MASP-1/-3 KO mouse sera demonstrated significantly decreased S2238 cleavage. rhMBL alone failed to cleave S2238, but cleavage was restored when rMASP-1 was added to either MASP-1/-3 KO sera or rhMBL. Taken together, these findings indicate that MBL/MASP complexes, and specifically MASP-1, play a key role in thrombus formation in vitro and in vivo."xsd:string |
| http://purl.uniprot.org/citations/22156595 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1102916"xsd:string |
| http://purl.uniprot.org/citations/22156595 | http://purl.uniprot.org/core/author | "Fujita T."xsd:string |
| http://purl.uniprot.org/citations/22156595 | http://purl.uniprot.org/core/author | "Takahashi K."xsd:string |
| http://purl.uniprot.org/citations/22156595 | http://purl.uniprot.org/core/author | "Takahashi M."xsd:string |
| http://purl.uniprot.org/citations/22156595 | http://purl.uniprot.org/core/author | "Tan Y.S."xsd:string |
| http://purl.uniprot.org/citations/22156595 | http://purl.uniprot.org/core/author | "Zou C."xsd:string |
| http://purl.uniprot.org/citations/22156595 | http://purl.uniprot.org/core/author | "Stahl G.L."xsd:string |
| http://purl.uniprot.org/citations/22156595 | http://purl.uniprot.org/core/author | "Banda N.K."xsd:string |
| http://purl.uniprot.org/citations/22156595 | http://purl.uniprot.org/core/author | "La Bonte L.R."xsd:string |
| http://purl.uniprot.org/citations/22156595 | http://purl.uniprot.org/core/author | "Pavlov V.I."xsd:string |
| http://purl.uniprot.org/citations/22156595 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22156595 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/22156595 | http://purl.uniprot.org/core/pages | "885-891"xsd:string |
| http://purl.uniprot.org/citations/22156595 | http://purl.uniprot.org/core/title | "Mannose-binding lectin-associated serine protease-1 is a significant contributor to coagulation in a murine model of occlusive thrombosis."xsd:string |
| http://purl.uniprot.org/citations/22156595 | http://purl.uniprot.org/core/volume | "188"xsd:string |
| http://purl.uniprot.org/citations/22156595 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22156595 |
| http://purl.uniprot.org/citations/22156595 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22156595 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHR3-mappedCitation-22156595 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22156595 |
| http://purl.uniprot.org/uniprot/#_A0A2C9F2B6-mappedCitation-22156595 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22156595 |
| http://purl.uniprot.org/uniprot/#_F6XQ00-mappedCitation-22156595 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22156595 |
| http://purl.uniprot.org/uniprot/#_B8JJM3-mappedCitation-22156595 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22156595 |
| http://purl.uniprot.org/uniprot/#_B8JJM5-mappedCitation-22156595 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22156595 |
| http://purl.uniprot.org/uniprot/#_B8JJM6-mappedCitation-22156595 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22156595 |