| http://purl.uniprot.org/citations/22157630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22157630 | http://www.w3.org/2000/01/rdf-schema#comment | "Infection of erythrocytes with Plasmodium species induces clinical malaria. Parasite-specific CD4(+) T cells correlate with lower parasite burdens and severity of human malaria and are needed to control blood-stage infection in mice. However, the characteristics of CD4(+) T cells that determine protection or parasite persistence remain unknown. Here we show that infection of humans with Plasmodium falciparum resulted in higher expression of the inhibitory receptor PD-1 associated with T cell dysfunction. In vivo blockade of the PD-1 ligand PD-L1 and the inhibitory receptor LAG-3 restored CD4(+) T cell function, amplified the number of follicular helper T cells and germinal-center B cells and plasmablasts, enhanced protective antibodies and rapidly cleared blood-stage malaria in mice. Thus, chronic malaria drives specific T cell dysfunction, and proper function can be restored by inhibitory therapies to enhance parasite control."xsd:string |
| http://purl.uniprot.org/citations/22157630 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.2180"xsd:string |
| http://purl.uniprot.org/citations/22157630 | http://purl.uniprot.org/core/author | "Moebius J."xsd:string |
| http://purl.uniprot.org/citations/22157630 | http://purl.uniprot.org/core/author | "Harty J.T."xsd:string |
| http://purl.uniprot.org/citations/22157630 | http://purl.uniprot.org/core/author | "Crompton P.D."xsd:string |
| http://purl.uniprot.org/citations/22157630 | http://purl.uniprot.org/core/author | "Doumbo O.K."xsd:string |
| http://purl.uniprot.org/citations/22157630 | http://purl.uniprot.org/core/author | "Waldschmidt T.J."xsd:string |
| http://purl.uniprot.org/citations/22157630 | http://purl.uniprot.org/core/author | "Traore B."xsd:string |
| http://purl.uniprot.org/citations/22157630 | http://purl.uniprot.org/core/author | "Tygrett L.T."xsd:string |
| http://purl.uniprot.org/citations/22157630 | http://purl.uniprot.org/core/author | "Butler N.S."xsd:string |
| http://purl.uniprot.org/citations/22157630 | http://purl.uniprot.org/core/author | "Pewe L.L."xsd:string |
| http://purl.uniprot.org/citations/22157630 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22157630 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/22157630 | http://purl.uniprot.org/core/pages | "188-195"xsd:string |
| http://purl.uniprot.org/citations/22157630 | http://purl.uniprot.org/core/title | "Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection."xsd:string |
| http://purl.uniprot.org/citations/22157630 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/22157630 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22157630 |
| http://purl.uniprot.org/citations/22157630 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22157630 |
| http://purl.uniprot.org/uniprot/#_Q3U472-mappedCitation-22157630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22157630 |
| http://purl.uniprot.org/uniprot/#_Q61790-mappedCitation-22157630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22157630 |
| http://purl.uniprot.org/uniprot/#_Q9EP73-mappedCitation-22157630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22157630 |
| http://purl.uniprot.org/uniprot/Q3U472 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22157630 |
| http://purl.uniprot.org/uniprot/Q9EP73 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22157630 |
| http://purl.uniprot.org/uniprot/Q61790 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22157630 |