| http://purl.uniprot.org/citations/22167058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22167058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22167058 | http://www.w3.org/2000/01/rdf-schema#comment | "Increased cellular ploidy is widespread during developmental processes of multicellular organisms, especially in plants. Elevated ploidy levels are typically achieved either by endoreplication or endomitosis, which are often regarded as modified cell cycles that lack an M phase either entirely or partially. We identified GIGAS CELL1 (GIG1)/OMISSION OF SECOND DIVISION1 (OSD1) and established that mutation of this gene triggered ectopic endomitosis. On the other hand, it has been reported that a paralog of GIG1/OSD1, UV-INSENSITIVE4 (UVI4), negatively regulates endoreplication onset in Arabidopsis thaliana. We showed that GIG1/OSD1 and UVI4 encode novel plant-specific inhibitors of the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. These proteins physically interact with APC/C activators, CDC20/FZY and CDH1/FZR, in yeast two-hybrid assays. Overexpression of CDC20.1 and CCS52B/FZR3 differentially promoted ectopic endomitosis in gig1/osd1 and premature occurrence of endoreplication in uvi4. Our data suggest that GIG1/OSD1 and UVI4 may prevent an unscheduled increase in cellular ploidy by preferentially inhibiting APC/C(CDC20) and APC/C(FZR), respectively. Generation of cells with a mixed identity in gig1/osd1 further suggested that the APC/C may have an unexpected role for cell fate determination in addition to its role for proper mitotic progression."xsd:string |
| http://purl.uniprot.org/citations/22167058 | http://purl.org/dc/terms/identifier | "doi:10.1105/tpc.111.092049"xsd:string |
| http://purl.uniprot.org/citations/22167058 | http://purl.org/dc/terms/identifier | "doi:10.1105/tpc.111.092049"xsd:string |
| http://purl.uniprot.org/citations/22167058 | http://purl.uniprot.org/core/author | "Matsunaga S."xsd:string |
| http://purl.uniprot.org/citations/22167058 | http://purl.uniprot.org/core/author | "Matsunaga S."xsd:string |
| http://purl.uniprot.org/citations/22167058 | http://purl.uniprot.org/core/author | "Ito M."xsd:string |
| http://purl.uniprot.org/citations/22167058 | http://purl.uniprot.org/core/author | "Ito M."xsd:string |
| http://purl.uniprot.org/citations/22167058 | http://purl.uniprot.org/core/author | "Genschik P."xsd:string |
| http://purl.uniprot.org/citations/22167058 | http://purl.uniprot.org/core/author | "Genschik P."xsd:string |
| http://purl.uniprot.org/citations/22167058 | http://purl.uniprot.org/core/author | "Yoshioka Y."xsd:string |
| http://purl.uniprot.org/citations/22167058 | http://purl.uniprot.org/core/author | "Yoshioka Y."xsd:string |
| http://purl.uniprot.org/citations/22167058 | http://purl.uniprot.org/core/author | "Ikeda S."xsd:string |
| http://purl.uniprot.org/citations/22167058 | http://purl.uniprot.org/core/author | "Ikeda S."xsd:string |
| http://purl.uniprot.org/citations/22167058 | http://purl.uniprot.org/core/author | "Kurata M."xsd:string |
| http://purl.uniprot.org/citations/22167058 | http://purl.uniprot.org/core/author | "Kurata M."xsd:string |
| http://purl.uniprot.org/citations/22167058 | http://purl.uniprot.org/core/author | "Criqui M.-C."xsd:string |
| http://purl.uniprot.org/citations/22167058 | http://purl.uniprot.org/core/author | "Criqui M.-C."xsd:string |
| http://purl.uniprot.org/citations/22167058 | http://purl.uniprot.org/core/author | "Iwata E."xsd:string |
| http://purl.uniprot.org/citations/22167058 | http://purl.uniprot.org/core/author | "Iwata E."xsd:string |
| http://purl.uniprot.org/citations/22167058 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22167058 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22167058 | http://purl.uniprot.org/core/name | "Plant Cell"xsd:string |
| http://purl.uniprot.org/citations/22167058 | http://purl.uniprot.org/core/name | "Plant Cell"xsd:string |