| http://purl.uniprot.org/citations/22172867 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22172867 | http://www.w3.org/2000/01/rdf-schema#comment | "Outcomes following lung transplant remain suboptimal. This is attributable to variable posttransplant recovery of lung function, and inconsistent degrees of lung function loss after peak function is reached. Granzyme B is elevated in the blood and bronchoalveolar lavage (BAL) in acute rejection. We hypothesized that persistent exposure to T cells high in granzyme B would negatively correlate with lung function. We investigated cumulative exposure measured as the area-under-the-curve (AUC) of CD8+ T cell granzyme Bhi cells in the first year posttransplant in both BAL and blood in 24 transplant recipients. We assessed the correlation between cumulative 1-year exposure and FEV1 slope. There was a negative correlation between 1-year exposure and FEV1 slope within the first year (r=-0.63; P=.001). This relationship persisted even when adjusted for transplant type, gender, age, rejection, and indication for transplantation. In contrast, no relationship was seen with the 1-year AUC and lung function after 1 year posttransplant. In contrast to the BAL granzyme Bhi levels, granzyme Bhi levels from the blood showed no relationship with lung function. These findings suggest that CD8+ T-cell-driven factors are responsible for early improvements in lung function after transplantation."xsd:string |
| http://purl.uniprot.org/citations/22172867 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.transproceed.2011.09.072"xsd:string |
| http://purl.uniprot.org/citations/22172867 | http://purl.uniprot.org/core/author | "Pickens A."xsd:string |
| http://purl.uniprot.org/citations/22172867 | http://purl.uniprot.org/core/author | "Mohammed A."xsd:string |
| http://purl.uniprot.org/citations/22172867 | http://purl.uniprot.org/core/author | "Fernandez F."xsd:string |
| http://purl.uniprot.org/citations/22172867 | http://purl.uniprot.org/core/author | "Lawrence E.C."xsd:string |
| http://purl.uniprot.org/citations/22172867 | http://purl.uniprot.org/core/author | "Kirk A.D."xsd:string |
| http://purl.uniprot.org/citations/22172867 | http://purl.uniprot.org/core/author | "Larsen C.P."xsd:string |
| http://purl.uniprot.org/citations/22172867 | http://purl.uniprot.org/core/author | "Gal A.A."xsd:string |
| http://purl.uniprot.org/citations/22172867 | http://purl.uniprot.org/core/author | "Ulukpo O."xsd:string |
| http://purl.uniprot.org/citations/22172867 | http://purl.uniprot.org/core/author | "Easley K.C."xsd:string |
| http://purl.uniprot.org/citations/22172867 | http://purl.uniprot.org/core/author | "Force S.D."xsd:string |
| http://purl.uniprot.org/citations/22172867 | http://purl.uniprot.org/core/author | "Neujahr D.C."xsd:string |
| http://purl.uniprot.org/citations/22172867 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22172867 | http://purl.uniprot.org/core/name | "Transplant Proc"xsd:string |
| http://purl.uniprot.org/citations/22172867 | http://purl.uniprot.org/core/pages | "3892-3898"xsd:string |
| http://purl.uniprot.org/citations/22172867 | http://purl.uniprot.org/core/title | "Cumulative exposure to CD8+ granzyme Bhi T cells is associated with reduced lung function early after lung transplantation."xsd:string |
| http://purl.uniprot.org/citations/22172867 | http://purl.uniprot.org/core/volume | "43"xsd:string |
| http://purl.uniprot.org/citations/22172867 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22172867 |
| http://purl.uniprot.org/citations/22172867 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22172867 |
| http://purl.uniprot.org/uniprot/#_P10144-mappedCitation-22172867 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22172867 |
| http://purl.uniprot.org/uniprot/#_J3KQ52-mappedCitation-22172867 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22172867 |
| http://purl.uniprot.org/uniprot/#_Q67BC3-mappedCitation-22172867 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22172867 |
| http://purl.uniprot.org/uniprot/#_Q6XGZ2-mappedCitation-22172867 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22172867 |