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| http://purl.uniprot.org/citations/22177953 | http://www.w3.org/2000/01/rdf-schema#comment | "MEK1 and MEK2 are related protein kinases that participate in the RAS-RAF-MEK-ERK signal transduction cascade. This cascade participates in the regulation of a large variety of processes including apoptosis, cell cycle progression, cell migration, differentiation, metabolism, and proliferation. Moreover, oncogenic mutations in RAS or B-RAF are responsible for a large proportion of human cancers. MEK1 is activated by phosphorylation of S218 and S222 in its activation segment as catalyzed by RAF kinases in an intricate process that involves a KSR scaffold. Besides functioning as a scaffold, the kinase activity of KSR is also required for MEK activation. MEK1 regulation is unusual in that S212 phosphorylation in its activation segment is inhibitory. Moreover, active ERK catalyzes a feedback inhibitory phosphorylation of MEK1 T292 that serves to downregulate the pathway."xsd:string |
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| http://purl.uniprot.org/citations/22177953 | http://purl.uniprot.org/core/author | "Roskoski R. Jr."xsd:string |
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| http://purl.uniprot.org/citations/22177953 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
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| http://purl.uniprot.org/citations/22177953 | http://purl.uniprot.org/core/title | "MEK1/2 dual-specificity protein kinases: structure and regulation."xsd:string |
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