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http://purl.uniprot.org/citations/22179112http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22179112http://www.w3.org/2000/01/rdf-schema#comment"L-DOPA-induced dyskinesia, the rate-limiting side effect in the therapy of Parkinson's disease, is mediated by activation of mammalian target of rapamycin (mTOR) signaling in the striatum. We found that Ras homolog enriched in striatum (Rhes), a striatal-specific protein, binds to and activates mTOR. Moreover, Rhes(-/-) mice showed reduced striatal mTOR signaling and diminished dyskinesia, but maintained motor improvement on L-DOPA treatment, suggesting a therapeutic benefit for Rhes-binding drugs."xsd:string
http://purl.uniprot.org/citations/22179112http://purl.org/dc/terms/identifier"doi:10.1038/nn.2994"xsd:string
http://purl.uniprot.org/citations/22179112http://purl.uniprot.org/core/author"Kim S."xsd:string
http://purl.uniprot.org/citations/22179112http://purl.uniprot.org/core/author"Subramaniam S."xsd:string
http://purl.uniprot.org/citations/22179112http://purl.uniprot.org/core/author"Tyagi R."xsd:string
http://purl.uniprot.org/citations/22179112http://purl.uniprot.org/core/author"Snyder S.H."xsd:string
http://purl.uniprot.org/citations/22179112http://purl.uniprot.org/core/author"Napolitano F."xsd:string
http://purl.uniprot.org/citations/22179112http://purl.uniprot.org/core/author"Barrow R."xsd:string
http://purl.uniprot.org/citations/22179112http://purl.uniprot.org/core/author"Errico F."xsd:string
http://purl.uniprot.org/citations/22179112http://purl.uniprot.org/core/author"Usiello A."xsd:string
http://purl.uniprot.org/citations/22179112http://purl.uniprot.org/core/author"Shahani N."xsd:string
http://purl.uniprot.org/citations/22179112http://purl.uniprot.org/core/author"Mealer R.G."xsd:string
http://purl.uniprot.org/citations/22179112http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/22179112http://purl.uniprot.org/core/name"Nat Neurosci"xsd:string
http://purl.uniprot.org/citations/22179112http://purl.uniprot.org/core/pages"191-193"xsd:string
http://purl.uniprot.org/citations/22179112http://purl.uniprot.org/core/title"Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA-induced dyskinesia."xsd:string
http://purl.uniprot.org/citations/22179112http://purl.uniprot.org/core/volume"15"xsd:string
http://purl.uniprot.org/citations/22179112http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22179112
http://purl.uniprot.org/citations/22179112http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/22179112
http://purl.uniprot.org/uniprot/#_P63032-mappedCitation-22179112http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22179112
http://purl.uniprot.org/uniprot/#_Q925G8-mappedCitation-22179112http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22179112
http://purl.uniprot.org/uniprot/#_Q3T9E1-mappedCitation-22179112http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22179112
http://purl.uniprot.org/uniprot/#_Q9JLN9-mappedCitation-22179112http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22179112
http://purl.uniprot.org/uniprot/#_Q8JZW1-mappedCitation-22179112http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22179112