| http://purl.uniprot.org/citations/22186370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22186370 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous studies have shown that female rats exhibit enhanced cocaine seeking during multiple phases of cocaine addiction compared with males. The orexin/hypocretin system recently has been implicated in drug addiction in male rats. Based on the known sex differences in cocaine addiction, in the current study we examined orexin-mediated cocaine seeking during self-administration, extinction, and reinstatement in age-matched male (initial weight 250-300 g) and female (initial weight 175-225 g) Sprague-Dawley rats by using the orexin-1 receptor (OX1R) antagonist 1-(2-methylbenzoxazol-6-yl)-3-[1,5]naphthyridin-4-yl urea (SB-334867) (10-30 mg/kg). OX1R blockade had no effect on established cocaine self-administration, but attenuated cocaine seeking during extinction in both male and female rats. It is noteworthy that OX1R blockade potently attenuated cue-induced reinstatement in males but had no effect on females. SB-334867 also reduced cocaine seeking during pharmacological stress-induced (yohimbine, 2.5 mg/kg) and yohimbine + cue-induced reinstatement in both sexes. SB-334867 failed to affect reinstatement induced by cocaine (10 mg/kg) in either male or female rats, but selectively reduced cocaine + cue-induced reinstatement only in males. In separate experiments examining basal and cocaine-induced locomotion, SB-334867 attenuated locomotion in both male and female rats. Finally, assessment of plasma and brain levels of SB-334867 showed that estrus females had slightly higher plasma levels than diestrus females, but no overall sex differences or estrous cycle differences were observed in plasma or brain SB-334867 concentrations. These results show that OX1R signaling plays a role in mediating cocaine seeking, but differs between the sexes for cue-induced reinstatement."xsd:string |
| http://purl.uniprot.org/citations/22186370 | http://purl.org/dc/terms/identifier | "doi:10.1124/jpet.111.187567"xsd:string |
| http://purl.uniprot.org/citations/22186370 | http://purl.uniprot.org/core/author | "Lin L."xsd:string |
| http://purl.uniprot.org/citations/22186370 | http://purl.uniprot.org/core/author | "Zhou L."xsd:string |
| http://purl.uniprot.org/citations/22186370 | http://purl.uniprot.org/core/author | "Chan C."xsd:string |
| http://purl.uniprot.org/citations/22186370 | http://purl.uniprot.org/core/author | "Kenny P.J."xsd:string |
| http://purl.uniprot.org/citations/22186370 | http://purl.uniprot.org/core/author | "Cameron M.D."xsd:string |
| http://purl.uniprot.org/citations/22186370 | http://purl.uniprot.org/core/author | "See R.E."xsd:string |
| http://purl.uniprot.org/citations/22186370 | http://purl.uniprot.org/core/author | "Ghee S.M."xsd:string |
| http://purl.uniprot.org/citations/22186370 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22186370 | http://purl.uniprot.org/core/name | "J Pharmacol Exp Ther"xsd:string |
| http://purl.uniprot.org/citations/22186370 | http://purl.uniprot.org/core/pages | "801-809"xsd:string |
| http://purl.uniprot.org/citations/22186370 | http://purl.uniprot.org/core/title | "Orexin-1 receptor mediation of cocaine seeking in male and female rats."xsd:string |
| http://purl.uniprot.org/citations/22186370 | http://purl.uniprot.org/core/volume | "340"xsd:string |
| http://purl.uniprot.org/citations/22186370 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22186370 |
| http://purl.uniprot.org/citations/22186370 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22186370 |
| http://purl.uniprot.org/uniprot/#_P56718-mappedCitation-22186370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22186370 |
| http://purl.uniprot.org/uniprot/#_A6ISN2-mappedCitation-22186370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22186370 |
| http://purl.uniprot.org/uniprot/A6ISN2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22186370 |
| http://purl.uniprot.org/uniprot/P56718 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22186370 |