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| http://purl.uniprot.org/citations/22187675 | http://www.w3.org/2000/01/rdf-schema#comment | "The class II release factor RF3 is a GTPase related to elongation factor EF-G, which catalyzes release of class I release factors RF1 and RF2 from the ribosome after termination of protein synthesis. The 3.3 Å crystal structure of the RF3·GDPNP·ribosome complex provides a high-resolution description of interactions and structural rearrangements that occur when binding of this translational GTPase induces large-scale rotational movements in the ribosome. RF3 induces a 7° rotation of the body and 14° rotation of the head of the 30S ribosomal subunit, and itself undergoes inter- and intradomain conformational rearrangements. We suggest that ordering of critical elements of switch loop I and the P loop, which help to form the GTPase catalytic site, are caused by interactions between the G domain of RF3 and the sarcin-ricin loop of 23S rRNA. The rotational movements in the ribosome induced by RF3, and its distinctly different binding orientation to the sarcin-ricin loop of 23S rRNA, raise interesting implications for the mechanism of action of EF-G in translocation."xsd:string |
| http://purl.uniprot.org/citations/22187675 | http://purl.org/dc/terms/identifier | "doi:10.1261/rna.031187.111"xsd:string |
| http://purl.uniprot.org/citations/22187675 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/22187675 | http://purl.uniprot.org/core/author | "Noller H.F."xsd:string |
| http://purl.uniprot.org/citations/22187675 | http://purl.uniprot.org/core/author | "Trakhanov S."xsd:string |
| http://purl.uniprot.org/citations/22187675 | http://purl.uniprot.org/core/author | "Lancaster L."xsd:string |
| http://purl.uniprot.org/citations/22187675 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22187675 | http://purl.uniprot.org/core/name | "RNA"xsd:string |
| http://purl.uniprot.org/citations/22187675 | http://purl.uniprot.org/core/pages | "230-240"xsd:string |
| http://purl.uniprot.org/citations/22187675 | http://purl.uniprot.org/core/title | "Crystal structure of release factor RF3 trapped in the GTP state on a rotated conformation of the ribosome."xsd:string |
| http://purl.uniprot.org/citations/22187675 | http://purl.uniprot.org/core/volume | "18"xsd:string |
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