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http://purl.uniprot.org/citations/22188742http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22188742http://www.w3.org/2000/01/rdf-schema#comment"

Context

Light exposure, particularly at the short-wavelength range, triggers several nonvisual responses in humans. However, the extent to which the melatonin-suppressing and alerting effect of light differs among individuals remains unknown.

Objective

Here we investigated whether blue-enriched polychromatic light impacts differentially on melatonin and subjective and objective alertness in healthy participants genotyped for the PERIOD3 (PER3) variable-number, tandem-repeat polymorphism.

Design, setting, and participants

Eighteen healthy young men homozygous for the PER3 polymorphism (PER3(5/5)and PER3(4/4)) underwent a balanced crossover design during the winter season, with light exposure to compact fluorescent lamps of 40 lux at 6500 K and at 2500 K during 2 h in the evening.

Results

In comparison to light at 2500 K, blue-enriched light at 6500 K induced a significant suppression of the evening rise in endogenous melatonin levels in PER3(5/5) individuals but not in PER3(4/4). Likewise, PER3(5/5) individuals exhibited a more pronounced alerting response to light at 6500 K than PER3(4/4) volunteers. Waking electroencephalographic activity in the theta range (5-7 Hz), a putative correlate of sleepiness, was drastically attenuated during light exposure at 6500 K in PER3(5/5) individuals as compared with PER3(4/4).

Conclusions

We provide first evidence that humans homozygous for the PER3 5/5 allele are particularly sensitive to blue-enriched light, as indexed by the suppression of endogenous melatonin and waking theta activity. Light sensitivity in humans may be modulated by a clock gene polymorphism implicated in the sleep-wake regulation."xsd:string
http://purl.uniprot.org/citations/22188742http://purl.org/dc/terms/identifier"doi:10.1210/jc.2011-2391"xsd:string
http://purl.uniprot.org/citations/22188742http://purl.uniprot.org/core/author"Maire M."xsd:string
http://purl.uniprot.org/citations/22188742http://purl.uniprot.org/core/author"Schmidt C."xsd:string
http://purl.uniprot.org/citations/22188742http://purl.uniprot.org/core/author"Bachmann V."xsd:string
http://purl.uniprot.org/citations/22188742http://purl.uniprot.org/core/author"Landolt H.P."xsd:string
http://purl.uniprot.org/citations/22188742http://purl.uniprot.org/core/author"Gotz T."xsd:string
http://purl.uniprot.org/citations/22188742http://purl.uniprot.org/core/author"Cajochen C."xsd:string
http://purl.uniprot.org/citations/22188742http://purl.uniprot.org/core/author"Gabel V."xsd:string
http://purl.uniprot.org/citations/22188742http://purl.uniprot.org/core/author"Reichert C.F."xsd:string
http://purl.uniprot.org/citations/22188742http://purl.uniprot.org/core/author"Viola A.U."xsd:string
http://purl.uniprot.org/citations/22188742http://purl.uniprot.org/core/author"Chellappa S.L."xsd:string
http://purl.uniprot.org/citations/22188742http://purl.uniprot.org/core/author"Valomon A."xsd:string
http://purl.uniprot.org/citations/22188742http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22188742http://purl.uniprot.org/core/name"J Clin Endocrinol Metab"xsd:string
http://purl.uniprot.org/citations/22188742http://purl.uniprot.org/core/pages"E433-7"xsd:string
http://purl.uniprot.org/citations/22188742http://purl.uniprot.org/core/title"Human melatonin and alerting response to blue-enriched light depend on a polymorphism in the clock gene PER3."xsd:string
http://purl.uniprot.org/citations/22188742http://purl.uniprot.org/core/volume"97"xsd:string
http://purl.uniprot.org/citations/22188742http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22188742
http://purl.uniprot.org/citations/22188742http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/22188742
http://purl.uniprot.org/uniprot/#_A0A087WV69-mappedCitation-22188742http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22188742
http://purl.uniprot.org/uniprot/#_P56645-mappedCitation-22188742http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22188742
http://purl.uniprot.org/uniprot/#_A2I2N5-mappedCitation-22188742http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22188742
http://purl.uniprot.org/uniprot/#_A6H8X0-mappedCitation-22188742http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22188742
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