| http://purl.uniprot.org/citations/22190577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22190577 | http://www.w3.org/2000/01/rdf-schema#comment | "The non-donor-specific anti-HLA-Ia antibodies correlate significantly with lower graft survival in organ transplant patients. Based on our earlier findings that anti-HLA-E murine monoclonal antibodies (MEM-E/02 and 3D12) reacted with different HLA-Ia alleles and the peptides shared by HLA-E and HLA class, Ia alleles inhibited the HLA-Ia reactivity of the anti-HLA-E antibodies in normal non-alloimmunized males, the possibility of that anti-HLA-E IgG may account for the non-donor-specific anti-HLA-Ia antibodies in the allograft recipients was examined by multiplex-Luminex®-immunoassay. About 73% of renal and 53% of liver transplant patients' sera with high level of anti-HLA-E IgG showed reactivity to different non-donor HLA-Ia alleles. About 50% renal and 52% liver allograft recipients' sera with low level of anti-HLA-E IgG had no reactivity to any HLA-Ia alleles; however, the IgG isolated from the same sera with protein-G columns showed the presence of anti-HLA-E IgG with HLA-Ia reactivity. Furthermore, both recombinant HLA-E and the IgG-free serum containing soluble HLA-E (sHLA-E) inhibited HLA-Ia reactivity of anti-HLA-E murine monoclonal IgG significantly. The data suggest that the HLA-Ia reactivity of the anti-HLA-E antibody accounts for the non-donor-specific anti-HLA-Ia antibodies. It is proposed that the sHLA-E heavy chain, shed in circulation after organ transplantation, may expose cryptic epitopes of HLA-E to elicit anti-HLA-E IgG antibodies, which may cross react with HLA-Ia alleles due to the peptide sequences shared between them. This study provides a new explanation for the presence of non-donor-specific antibodies for non-existing HLA-Ia alleles, frequently observed and correlated with survival in organ transplant recipients."xsd:string |
| http://purl.uniprot.org/citations/22190577 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/dxr094"xsd:string |
| http://purl.uniprot.org/citations/22190577 | http://purl.uniprot.org/core/author | "Pham T."xsd:string |
| http://purl.uniprot.org/citations/22190577 | http://purl.uniprot.org/core/author | "Ozawa M."xsd:string |
| http://purl.uniprot.org/citations/22190577 | http://purl.uniprot.org/core/author | "Terasaki P.I."xsd:string |
| http://purl.uniprot.org/citations/22190577 | http://purl.uniprot.org/core/author | "Ravindranath M.H."xsd:string |
| http://purl.uniprot.org/citations/22190577 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22190577 | http://purl.uniprot.org/core/name | "Int Immunol"xsd:string |
| http://purl.uniprot.org/citations/22190577 | http://purl.uniprot.org/core/pages | "43-57"xsd:string |
| http://purl.uniprot.org/citations/22190577 | http://purl.uniprot.org/core/title | "Antibodies to HLA-E may account for the non-donor-specific anti-HLA class-Ia antibodies in renal and liver transplant recipients."xsd:string |
| http://purl.uniprot.org/citations/22190577 | http://purl.uniprot.org/core/volume | "24"xsd:string |
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