| http://purl.uniprot.org/citations/22194696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22194696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22194696 | http://www.w3.org/2000/01/rdf-schema#comment | "Caenorhabditis elegans ftn-1 and ftn-2, which encode the iron-storage protein ferritin, are transcriptionally inhibited during iron deficiency in intestine. Intestinal specific transcription is dependent on binding of ELT-2 to GATA binding sites in an iron-dependent enhancer (IDE) located in ftn-1 and ftn-2 promoters, but the mechanism for iron regulation is unknown. Here, we identify HIF-1 (hypoxia-inducible factor -1) as a negative regulator of ferritin transcription. HIF-1 binds to hypoxia-response elements (HREs) in the IDE in vitro and in vivo. Depletion of hif-1 by RNA interference blocks transcriptional inhibition of ftn-1 and ftn-2 reporters, and ftn-1 and ftn-2 mRNAs are not regulated in a hif-1 null strain during iron deficiency. An IDE is also present in smf-3 encoding a protein homologous to mammalian divalent metal transporter-1. Unlike the ftn-1 IDE, the smf-3 IDE is required for HIF-1-dependent transcriptional activation of smf-3 during iron deficiency. We show that hif-1 null worms grown under iron limiting conditions are developmentally delayed and that depletion of FTN-1 and FTN-2 rescues this phenotype. These data show that HIF-1 regulates intestinal iron homeostasis during iron deficiency by activating and inhibiting genes involved in iron uptake and storage."xsd:string |
| http://purl.uniprot.org/citations/22194696 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1002394"xsd:string |
| http://purl.uniprot.org/citations/22194696 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1002394"xsd:string |
| http://purl.uniprot.org/citations/22194696 | http://purl.uniprot.org/core/author | "Leibold E.A."xsd:string |
| http://purl.uniprot.org/citations/22194696 | http://purl.uniprot.org/core/author | "Leibold E.A."xsd:string |
| http://purl.uniprot.org/citations/22194696 | http://purl.uniprot.org/core/author | "Thacker C."xsd:string |
| http://purl.uniprot.org/citations/22194696 | http://purl.uniprot.org/core/author | "Thacker C."xsd:string |
| http://purl.uniprot.org/citations/22194696 | http://purl.uniprot.org/core/author | "Newman B.S."xsd:string |
| http://purl.uniprot.org/citations/22194696 | http://purl.uniprot.org/core/author | "Newman B.S."xsd:string |
| http://purl.uniprot.org/citations/22194696 | http://purl.uniprot.org/core/author | "Romney S.J."xsd:string |
| http://purl.uniprot.org/citations/22194696 | http://purl.uniprot.org/core/author | "Romney S.J."xsd:string |
| http://purl.uniprot.org/citations/22194696 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22194696 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22194696 | http://purl.uniprot.org/core/name | "PLoS Genet."xsd:string |
| http://purl.uniprot.org/citations/22194696 | http://purl.uniprot.org/core/name | "PLoS Genet."xsd:string |
| http://purl.uniprot.org/citations/22194696 | http://purl.uniprot.org/core/pages | "E1002394"xsd:string |
| http://purl.uniprot.org/citations/22194696 | http://purl.uniprot.org/core/pages | "E1002394"xsd:string |
| http://purl.uniprot.org/citations/22194696 | http://purl.uniprot.org/core/title | "HIF-1 regulates iron homeostasis in Caenorhabditis elegans by activation and inhibition of genes involved in iron uptake and storage."xsd:string |
| http://purl.uniprot.org/citations/22194696 | http://purl.uniprot.org/core/title | "HIF-1 regulates iron homeostasis in Caenorhabditis elegans by activation and inhibition of genes involved in iron uptake and storage."xsd:string |
| http://purl.uniprot.org/citations/22194696 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/22194696 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/22194696 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22194696 |
| http://purl.uniprot.org/citations/22194696 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22194696 |