| http://purl.uniprot.org/citations/22195744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22195744 | http://www.w3.org/2000/01/rdf-schema#comment | "To fulfill the bioenergetic and biosynthetic demand of proliferation, T cells reprogram their metabolic pathways from fatty acid β-oxidation and pyruvate oxidation via the TCA cycle to the glycolytic, pentose-phosphate, and glutaminolytic pathways. Two of the top-ranked candidate transcription factors potentially responsible for the activation-induced T cell metabolic transcriptome, HIF1α and Myc, were induced upon T cell activation, but only the acute deletion of Myc markedly inhibited activation-induced glycolysis and glutaminolysis in T cells. Glutamine deprivation compromised activation-induced T cell growth and proliferation, and this was partially replaced by nucleotides and polyamines, implicating glutamine as an important source for biosynthetic precursors in active T cells. Metabolic tracer analysis revealed a Myc-dependent metabolic pathway linking glutaminolysis to the biosynthesis of polyamines. Therefore, a Myc-dependent global metabolic transcriptome drives metabolic reprogramming in activated, primary T lymphocytes. This may represent a general mechanism for metabolic reprogramming under patho-physiological conditions."xsd:string |
| http://purl.uniprot.org/citations/22195744 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2011.09.021"xsd:string |
| http://purl.uniprot.org/citations/22195744 | http://purl.uniprot.org/core/author | "Wang R."xsd:string |
| http://purl.uniprot.org/citations/22195744 | http://purl.uniprot.org/core/author | "Chi H."xsd:string |
| http://purl.uniprot.org/citations/22195744 | http://purl.uniprot.org/core/author | "Carter R."xsd:string |
| http://purl.uniprot.org/citations/22195744 | http://purl.uniprot.org/core/author | "Milasta S."xsd:string |
| http://purl.uniprot.org/citations/22195744 | http://purl.uniprot.org/core/author | "Fitzgerald P."xsd:string |
| http://purl.uniprot.org/citations/22195744 | http://purl.uniprot.org/core/author | "Finkelstein D."xsd:string |
| http://purl.uniprot.org/citations/22195744 | http://purl.uniprot.org/core/author | "Green D.R."xsd:string |
| http://purl.uniprot.org/citations/22195744 | http://purl.uniprot.org/core/author | "Munger J."xsd:string |
| http://purl.uniprot.org/citations/22195744 | http://purl.uniprot.org/core/author | "Dillon C.P."xsd:string |
| http://purl.uniprot.org/citations/22195744 | http://purl.uniprot.org/core/author | "Shi L.Z."xsd:string |
| http://purl.uniprot.org/citations/22195744 | http://purl.uniprot.org/core/author | "McCormick L.L."xsd:string |
| http://purl.uniprot.org/citations/22195744 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22195744 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/22195744 | http://purl.uniprot.org/core/pages | "871-882"xsd:string |
| http://purl.uniprot.org/citations/22195744 | http://purl.uniprot.org/core/title | "The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation."xsd:string |
| http://purl.uniprot.org/citations/22195744 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/22195744 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22195744 |
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| http://purl.uniprot.org/uniprot/#_A0A0R4J1F0-mappedCitation-22195744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22195744 |
| http://purl.uniprot.org/uniprot/#_E0CZD1-mappedCitation-22195744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22195744 |
| http://purl.uniprot.org/uniprot/#_A0A158SIS7-mappedCitation-22195744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22195744 |