| http://purl.uniprot.org/citations/22197078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22197078 | http://www.w3.org/2000/01/rdf-schema#comment | "Injury to neurons results in up-regulation of galanin in some central and peripheral systems, and it has been suggested that this neuropeptide may play a protective and trophic role, primarily mediated by galanin receptor 2 (GalR2). The objective of the present study was to investigate galanin, GalR1, GalR2 and GalR3 gene expression in the female rat brain 7 days after a 60-min unilateral occlusion of the middle cerebral artery followed by reperfusion. Quantitative real-time PCR was employed in punch-biopsies from the locus coeruleus, somatosensory cortex and dorsal hippocampal formation, including sham-operated rats as controls. Galanin gene expression showed a ∼2.5-fold increase and GalR1 a ∼1.5-fold increase in the locus coeruleus of the ischemic hemisphere compared to the control side. Furthermore, the GalR1 mRNA levels decreased by 35% in somatosensory cortex of the ischemic hemisphere. Immunohistochemical analysis indicated a depletion of galanin from cell bodies and dendrites in the locus coeruleus after middle cerebral artery occlusion. The present results suggest that a stroke-induced forebrain lesion up-regulates synthesis of galanin and GalR1 in the locus coeruleus, a noradrenergic cell group projecting to many forebrain areas, including cortex and the hippocampal formation. These results support the notion that galanin may play a role in the response of the central nervous system to injury."xsd:string |
| http://purl.uniprot.org/citations/22197078 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.npep.2011.11.001"xsd:string |
| http://purl.uniprot.org/citations/22197078 | http://purl.uniprot.org/core/author | "Holm L."xsd:string |
| http://purl.uniprot.org/citations/22197078 | http://purl.uniprot.org/core/author | "Hokfelt T."xsd:string |
| http://purl.uniprot.org/citations/22197078 | http://purl.uniprot.org/core/author | "Hilke S."xsd:string |
| http://purl.uniprot.org/citations/22197078 | http://purl.uniprot.org/core/author | "Theodorsson E."xsd:string |
| http://purl.uniprot.org/citations/22197078 | http://purl.uniprot.org/core/author | "Adori C."xsd:string |
| http://purl.uniprot.org/citations/22197078 | http://purl.uniprot.org/core/author | "Theodorsson A."xsd:string |
| http://purl.uniprot.org/citations/22197078 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22197078 | http://purl.uniprot.org/core/name | "Neuropeptides"xsd:string |
| http://purl.uniprot.org/citations/22197078 | http://purl.uniprot.org/core/pages | "19-27"xsd:string |
| http://purl.uniprot.org/citations/22197078 | http://purl.uniprot.org/core/title | "Changes in galanin and GalR1 gene expression in discrete brain regions after transient occlusion of the middle cerebral artery in female rats."xsd:string |
| http://purl.uniprot.org/citations/22197078 | http://purl.uniprot.org/core/volume | "46"xsd:string |
| http://purl.uniprot.org/citations/22197078 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22197078 |
| http://purl.uniprot.org/citations/22197078 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22197078 |
| http://purl.uniprot.org/uniprot/#_A6K5J0-mappedCitation-22197078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22197078 |
| http://purl.uniprot.org/uniprot/#_Q62805-mappedCitation-22197078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22197078 |
| http://purl.uniprot.org/uniprot/#_Q62828-mappedCitation-22197078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22197078 |
| http://purl.uniprot.org/uniprot/A6K5J0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22197078 |
| http://purl.uniprot.org/uniprot/Q62805 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22197078 |
| http://purl.uniprot.org/uniprot/Q62828 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22197078 |