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| http://purl.uniprot.org/citations/22198437 | http://www.w3.org/2000/01/rdf-schema#comment | "The glucagon receptor (Gcgr) is essential for maintaining glucose homeostasis in the liver and for stimulating insulin secretion in pancreatic β-cells. Glucose induces rat Gcgr mRNA expression; however, the precise mechanism remains unknown. We previously have studied the role of the carbohydrate response element binding protein (ChREBP), a glucose-activated transcription factor, in the regulation of glucose-stimulated gene expression. The G-box has previously been reported to be responsible for glucose regulation of Gcgr mRNA expression. The G-box comprises two E-boxes separated by 3bp, which distinguishes it from the carbohydrate response element (ChoRE), which has 5-bp spacing between the two E-boxes. In the rat Gcgr promoter, a putative ChoRE (-554bp/-538bp) is localized near the G-box (-543bp/-529bp). In rat INS-1E insulinoma cells, deletion studies of the rat Gcgr promoter show that ChoRE is a minimal glucose response element. Moreover, reporter assays using a pGL3 promoter vector, which harbors ChoRE and chromatin immunoprecipitation assays reveal that ChoRE is a functional glucose response element in the rat Gcgr promoter. Furthermore, In contrast, glucagon partly suppresses glucose-induced expression of Gcgr mRNA. Thus, ChREBP directly regulates rat Gcgr expression in INS-1E cells. In addition, negative feedback looping between ChREBP and GCGR may further contribute to the regulation of glucose-induced gene expression."xsd:string |
| http://purl.uniprot.org/citations/22198437 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2011.12.042"xsd:string |
| http://purl.uniprot.org/citations/22198437 | http://purl.uniprot.org/core/author | "Takeda J."xsd:string |
| http://purl.uniprot.org/citations/22198437 | http://purl.uniprot.org/core/author | "Horikawa Y."xsd:string |
| http://purl.uniprot.org/citations/22198437 | http://purl.uniprot.org/core/author | "Tomita R."xsd:string |
| http://purl.uniprot.org/citations/22198437 | http://purl.uniprot.org/core/author | "Iizuka K."xsd:string |
| http://purl.uniprot.org/citations/22198437 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22198437 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/22198437 | http://purl.uniprot.org/core/pages | "1107-1112"xsd:string |
| http://purl.uniprot.org/citations/22198437 | http://purl.uniprot.org/core/title | "Rat glucagon receptor mRNA is directly regulated by glucose through transactivation of the carbohydrate response element binding protein."xsd:string |
| http://purl.uniprot.org/citations/22198437 | http://purl.uniprot.org/core/volume | "417"xsd:string |
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