| http://purl.uniprot.org/citations/22199361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22199361 | http://www.w3.org/2000/01/rdf-schema#comment | "SF-1 is a key transcription factor for all steroidogenic genes. It up-regulates the expression of the steroidogenic Cyp11a1 gene in the adrenal in a pathway stimulated by cAMP through HIPK3-mediated JNK/c-Jun phosphorylation. In the present study, we have investigated the factors mediating cAMP-dependent HIPK3 action to potentiate the activity of SF-1 for Cyp11a1 transcription in mouse adrenocortical Y1 cells. We found Daxx, a HIPK kinase substrate in the apoptosis pathway, was phosphorylated by HIPK3 at Ser-669 in response to cAMP stimulation. Daxx participated in SF-1-dependent Cyp11a1 expression as shown by experiments involving both overexpression and down-regulation via a dominant negative Daxx mutant. The S669A mutant of Daxx, which could not be phosphorylated by HIPK3, lost the ability to potentiate SF-1 activity for Cyp11a1 expression. The enhancement of SF-1 activity by Daxx required JNK and c-Jun phosphorylation. Thus, Daxx functioned as a signal transducer linking cAMP-stimulated HIPK3 activity with JNK/c-Jun phosphorylation and SF-1-dependent Cyp11a1 transcription for steroid synthesis."xsd:string |
| http://purl.uniprot.org/citations/22199361 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m111.307603"xsd:string |
| http://purl.uniprot.org/citations/22199361 | http://purl.uniprot.org/core/author | "Chung B.C."xsd:string |
| http://purl.uniprot.org/citations/22199361 | http://purl.uniprot.org/core/author | "Shih H.M."xsd:string |
| http://purl.uniprot.org/citations/22199361 | http://purl.uniprot.org/core/author | "Wu C.F."xsd:string |
| http://purl.uniprot.org/citations/22199361 | http://purl.uniprot.org/core/author | "Lan H.C."xsd:string |
| http://purl.uniprot.org/citations/22199361 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22199361 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/22199361 | http://purl.uniprot.org/core/pages | "5910-5916"xsd:string |
| http://purl.uniprot.org/citations/22199361 | http://purl.uniprot.org/core/title | "Death-associated protein 6 (Daxx) mediates cAMP-dependent stimulation of Cyp11a1 (P450scc) transcription."xsd:string |
| http://purl.uniprot.org/citations/22199361 | http://purl.uniprot.org/core/volume | "287"xsd:string |
| http://purl.uniprot.org/citations/22199361 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22199361 |
| http://purl.uniprot.org/citations/22199361 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22199361 |
| http://purl.uniprot.org/uniprot/#_A0A024RCS3-mappedCitation-22199361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22199361 |
| http://purl.uniprot.org/uniprot/#_A0A068BEP5-mappedCitation-22199361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22199361 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3T5-mappedCitation-22199361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22199361 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3M2-mappedCitation-22199361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22199361 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3R3-mappedCitation-22199361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22199361 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3H9-mappedCitation-22199361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22199361 |
| http://purl.uniprot.org/uniprot/#_A0A1U9X7L0-mappedCitation-22199361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22199361 |
| http://purl.uniprot.org/uniprot/#_B4DDI3-mappedCitation-22199361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22199361 |
| http://purl.uniprot.org/uniprot/#_B4DDJ0-mappedCitation-22199361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22199361 |
| http://purl.uniprot.org/uniprot/#_A1A558-mappedCitation-22199361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22199361 |
| http://purl.uniprot.org/uniprot/#_A8K8D6-mappedCitation-22199361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22199361 |