| http://purl.uniprot.org/citations/22200570 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22200570 | http://www.w3.org/2000/01/rdf-schema#comment | "Abstract Hyperhomocysteinemia has recently been identified as an important risk factor for Alzheimer's disease (AD). One of the potential mechanisms underlying harmful effects of homocysteine (Hcy) is site-specific acylation of proteins at lysine residues by homocysteine thiolactone (HCTL). The accumulation of amyloid β-peptide (Aβ) in the brain is a neuropathological hallmark of AD. In the present study we were interested to investigate the effects of N-homocysteinylation on the aggregation propensity and neurotoxicity of Aβ(1-42). By coupling several techniques, we demonstrated that the homocysteinylation of lysine residues increase the neurotoxicity of the Aβ peptide by stabilizing soluble oligomeric intermediates."xsd:string |
| http://purl.uniprot.org/citations/22200570 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2011.12.018"xsd:string |
| http://purl.uniprot.org/citations/22200570 | http://purl.uniprot.org/core/author | "Ahmadian S."xsd:string |
| http://purl.uniprot.org/citations/22200570 | http://purl.uniprot.org/core/author | "Aryapour H."xsd:string |
| http://purl.uniprot.org/citations/22200570 | http://purl.uniprot.org/core/author | "Hoveizi E."xsd:string |
| http://purl.uniprot.org/citations/22200570 | http://purl.uniprot.org/core/author | "Karima O."xsd:string |
| http://purl.uniprot.org/citations/22200570 | http://purl.uniprot.org/core/author | "Khodadadi S."xsd:string |
| http://purl.uniprot.org/citations/22200570 | http://purl.uniprot.org/core/author | "Riazi G.H."xsd:string |
| http://purl.uniprot.org/citations/22200570 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22200570 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/22200570 | http://purl.uniprot.org/core/pages | "127-131"xsd:string |
| http://purl.uniprot.org/citations/22200570 | http://purl.uniprot.org/core/title | "Effect of N-homocysteinylation on physicochemical and cytotoxic properties of amyloid beta-peptide."xsd:string |
| http://purl.uniprot.org/citations/22200570 | http://purl.uniprot.org/core/volume | "586"xsd:string |
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| http://purl.uniprot.org/uniprot/P05067#attribution-E0D5EA728AA8BE887FB9D4D403D67AE8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22200570 |
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| http://purl.uniprot.org/uniprot/#_B4DQM1-mappedCitation-22200570 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22200570 |
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