| http://purl.uniprot.org/citations/22200605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22200605 | http://www.w3.org/2000/01/rdf-schema#comment | "Thymine DNA glycosylase (TDG) is involved in the repair of G:T and G:U mismatches caused by hydrolytic deamination of 5-methylcytosine and cytosine, respectively. Recent studies have shown that TDG not only has G-T/U glycosylase activities but also acts in the maintaining proper epigenetic status. In order to investigate the function of TDG in vivo, mice lacking Tdg, Tdg (-/-), were generated. Tdg mutant mice died in utero by 11.5 days post coitum (dpc), although there were no significant differences in the spontaneous mutant frequencies between wild type and Tdg (-/-) embryos. On the other hand, the levels of noradrenaline in 10.5 dpc whole embryos, which is necessary for normal embryogenesis, were dramatically reduced in Tdg (-/-) embryos. Consequently, we tested the effect of D, L-threo-3, 4-dihydroxyphenylserine (DOPS), a synthetic precursor of noradrenaline, on the survival of the Tdg (-/-) embryos. DOPS was given to pregnant Tdg (+/-) mice from 6.5 dpc through drinking water. Most of the Tdg (-/-) embryos were alive at 11.5 dpc, and they were partially rescued up to 14.5 dpc by the administration of DOPS. In contrast, the administration of L-3, 4-dihydroxyphenylalanine (L-DOPA) had marginal effects on Tdg (-/-) embryonic lethality. No embryo was alive without DOPS beyond 11.5 dpc, suggesting that the lethality in (-/-) embryos is partially due to the reduction of noradrenaline. These results suggest that embryonic lethality in Tdg (-/-) embryos is due, in part, to the reduction of noradrenaline levels."xsd:string |
| http://purl.uniprot.org/citations/22200605 | http://purl.org/dc/terms/identifier | "doi:10.1620/tjem.226.75"xsd:string |
| http://purl.uniprot.org/citations/22200605 | http://purl.uniprot.org/core/author | "Ono T."xsd:string |
| http://purl.uniprot.org/citations/22200605 | http://purl.uniprot.org/core/author | "Saito Y."xsd:string |
| http://purl.uniprot.org/citations/22200605 | http://purl.uniprot.org/core/author | "Seki M."xsd:string |
| http://purl.uniprot.org/citations/22200605 | http://purl.uniprot.org/core/author | "Takeda N."xsd:string |
| http://purl.uniprot.org/citations/22200605 | http://purl.uniprot.org/core/author | "Nohmi T."xsd:string |
| http://purl.uniprot.org/citations/22200605 | http://purl.uniprot.org/core/author | "Noda T."xsd:string |
| http://purl.uniprot.org/citations/22200605 | http://purl.uniprot.org/core/author | "Enomoto T."xsd:string |
| http://purl.uniprot.org/citations/22200605 | http://purl.uniprot.org/core/author | "Uehara Y."xsd:string |
| http://purl.uniprot.org/citations/22200605 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22200605 | http://purl.uniprot.org/core/name | "Tohoku J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/22200605 | http://purl.uniprot.org/core/pages | "75-83"xsd:string |
| http://purl.uniprot.org/citations/22200605 | http://purl.uniprot.org/core/title | "Embryonic lethality in mice lacking mismatch-specific thymine DNA glycosylase is partially prevented by DOPS, a precursor of noradrenaline."xsd:string |
| http://purl.uniprot.org/citations/22200605 | http://purl.uniprot.org/core/volume | "226"xsd:string |
| http://purl.uniprot.org/citations/22200605 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22200605 |
| http://purl.uniprot.org/citations/22200605 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22200605 |
| http://purl.uniprot.org/uniprot/#_E9Q9G5-mappedCitation-22200605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22200605 |
| http://purl.uniprot.org/uniprot/#_P56581-mappedCitation-22200605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22200605 |
| http://purl.uniprot.org/uniprot/#_D3Z417-mappedCitation-22200605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22200605 |
| http://purl.uniprot.org/uniprot/#_O35958-mappedCitation-22200605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22200605 |
| http://purl.uniprot.org/uniprot/#_O88533-mappedCitation-22200605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22200605 |
| http://purl.uniprot.org/uniprot/#_D3Z0B1-mappedCitation-22200605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22200605 |
| http://purl.uniprot.org/uniprot/#_D6RGQ9-mappedCitation-22200605 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22200605 |