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| http://purl.uniprot.org/citations/22219353 | http://www.w3.org/2000/01/rdf-schema#comment | "We performed an in depth analysis of Bmp4, a critical regulator of development, disease, and evolution, in cranial neural crest (CNC). Conditional Bmp4 overexpression, using a tetracycline-regulated Bmp4 gain-of-function allele, resulted in facial skeletal changes that were most dramatic after an E10.5 Bmp4 induction. Expression profiling uncovered a signature of Bmp4-induced genes (BIG) composed predominantly of transcriptional regulators that control self-renewal, osteoblast differentiation and negative Bmp autoregulation. The complimentary experiment, CNC inactivation of Bmp2, Bmp4 and Bmp7, resulted in complete or partial loss of multiple CNC-derived skeletal elements, revealing a crucial requirement for Bmp signaling in membranous bone and cartilage development. Importantly, the BIG signature was reduced in Bmp loss-of-function mutants, indicating Bmp-regulated target genes are modulated by Bmp dose. Chromatin immunoprecipitation (ChIP) revealed a subset of the BIG signature, including Satb2, Smad6, Hand1, Gadd45γ and Gata3, that was bound by Smad1/5 in the developing mandible, revealing direct Smad-mediated regulation. These data support the hypothesis that Bmp signaling regulates craniofacial skeletal development by balancing self-renewal and differentiation pathways in CNC progenitors."xsd:string |
| http://purl.uniprot.org/citations/22219353 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.073197"xsd:string |
| http://purl.uniprot.org/citations/22219353 | http://purl.uniprot.org/core/author | "Bai Y."xsd:string |
| http://purl.uniprot.org/citations/22219353 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/22219353 | http://purl.uniprot.org/core/author | "Martin J.F."xsd:string |
| http://purl.uniprot.org/citations/22219353 | http://purl.uniprot.org/core/author | "Selever J."xsd:string |
| http://purl.uniprot.org/citations/22219353 | http://purl.uniprot.org/core/author | "Klysik E."xsd:string |
| http://purl.uniprot.org/citations/22219353 | http://purl.uniprot.org/core/author | "Bonilla-Claudio M."xsd:string |
| http://purl.uniprot.org/citations/22219353 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22219353 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/22219353 | http://purl.uniprot.org/core/pages | "709-719"xsd:string |
| http://purl.uniprot.org/citations/22219353 | http://purl.uniprot.org/core/title | "Bmp signaling regulates a dose-dependent transcriptional program to control facial skeletal development."xsd:string |
| http://purl.uniprot.org/citations/22219353 | http://purl.uniprot.org/core/volume | "139"xsd:string |
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