| http://purl.uniprot.org/citations/22222211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22222211 | http://www.w3.org/2000/01/rdf-schema#comment | "Ebola (EBOV) and Marburg virus (MARV) cause severe hemorrhagic fever. The host cell proteases cathepsin B and L activate the Zaire ebolavirus glycoprotein (GP) for cellular entry and constitute potential targets for antiviral intervention. However, it is unclear if different EBOV species and MARV equally depend on cathepsin B/L activity for infection of cell lines and macrophages, important viral target cells. Here, we show that cathepsin B/L inhibitors markedly reduce 293T cell infection driven by the GPs of all EBOV species, independent of the type II transmembrane serine protease TMPRSS2, which cleaved but failed to activate EBOV-GPs. Similarly, a cathepsin B/L inhibitor blocked macrophage infection mediated by different EBOV-GPs. In contrast, MARV-GP-driven entry exhibited little dependence on cathepsin B/L activity. Still, MARV-GP-mediated entry was efficiently blocked by leupeptin. These results suggest that cathepsins B/L promote entry of EBOV while MARV might employ so far unidentified proteases for GP activation."xsd:string |
| http://purl.uniprot.org/citations/22222211 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.virol.2011.11.031"xsd:string |
| http://purl.uniprot.org/citations/22222211 | http://purl.uniprot.org/core/author | "Hofmann H."xsd:string |
| http://purl.uniprot.org/citations/22222211 | http://purl.uniprot.org/core/author | "Pohlmann S."xsd:string |
| http://purl.uniprot.org/citations/22222211 | http://purl.uniprot.org/core/author | "Kaup F."xsd:string |
| http://purl.uniprot.org/citations/22222211 | http://purl.uniprot.org/core/author | "Glowacka I."xsd:string |
| http://purl.uniprot.org/citations/22222211 | http://purl.uniprot.org/core/author | "Kuhl A."xsd:string |
| http://purl.uniprot.org/citations/22222211 | http://purl.uniprot.org/core/author | "Bertram S."xsd:string |
| http://purl.uniprot.org/citations/22222211 | http://purl.uniprot.org/core/author | "Gnirss K."xsd:string |
| http://purl.uniprot.org/citations/22222211 | http://purl.uniprot.org/core/author | "Karsten C."xsd:string |
| http://purl.uniprot.org/citations/22222211 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22222211 | http://purl.uniprot.org/core/name | "Virology"xsd:string |
| http://purl.uniprot.org/citations/22222211 | http://purl.uniprot.org/core/pages | "3-10"xsd:string |
| http://purl.uniprot.org/citations/22222211 | http://purl.uniprot.org/core/title | "Cathepsins B and L activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages independent of TMPRSS2 expression."xsd:string |
| http://purl.uniprot.org/citations/22222211 | http://purl.uniprot.org/core/volume | "424"xsd:string |
| http://purl.uniprot.org/citations/22222211 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22222211 |
| http://purl.uniprot.org/citations/22222211 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22222211 |
| http://purl.uniprot.org/uniprot/#_A0A024R374-mappedCitation-22222211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22222211 |
| http://purl.uniprot.org/uniprot/#_A8K2H4-mappedCitation-22222211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22222211 |
| http://purl.uniprot.org/uniprot/#_A5PLM9-mappedCitation-22222211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22222211 |
| http://purl.uniprot.org/uniprot/#_B3KUJ8-mappedCitation-22222211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22222211 |
| http://purl.uniprot.org/uniprot/#_B3KQK4-mappedCitation-22222211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22222211 |
| http://purl.uniprot.org/uniprot/#_B4DMY4-mappedCitation-22222211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22222211 |
| http://purl.uniprot.org/uniprot/#_B4DL49-mappedCitation-22222211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22222211 |