| http://purl.uniprot.org/citations/22229156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22229156 | http://www.w3.org/2000/01/rdf-schema#comment | "Treg cells maintain the tumor microenvironment in an immunosuppressive state preventing an effective anti-tumor immune response. A possible strategy to overcome Treg-cell suppression focuses on OX40, a costimulatory molecule expressed constitutively by Treg cells while being induced in activated effector T cells. OX40 stimulation, by the agonist mAb OX86, inhibits Treg-cell suppression and boosts effector T-cell activation. Here we uncover the mechanisms underlying the therapeutic activity of OX86 treatment dissecting its distinct effects on Treg and on effector memory T (Tem) cells, the most abundant CD4+ populations strongly expressing OX40 at the tumor site. In response to OX86, tumor-infiltrating Treg cells produced significantly less interleukin 10 (IL-10), possibly in relation to a decrease in the transcription factor interferon regulatory factor 1 (IRF1). Tem cells responded to OX86 by upregulating surface CD40L expression, providing a licensing signal to DCs. The CD40L/CD40 axis was required for Tem-cell-mediated in vitro DC maturation and in vivo DC migration. Accordingly, OX86 treatment was no longer therapeutic in CD40 KO mice. In conclusion, following OX40 stimulation, blockade of Treg-cell suppression and enhancement of the Tem-cell adjuvant effect both concurred to free DCs from immunosuppression and activate the immune response against the tumor."xsd:string |
| http://purl.uniprot.org/citations/22229156 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201141700"xsd:string |
| http://purl.uniprot.org/citations/22229156 | http://purl.uniprot.org/core/author | "Piconese S."xsd:string |
| http://purl.uniprot.org/citations/22229156 | http://purl.uniprot.org/core/author | "Colombo M.P."xsd:string |
| http://purl.uniprot.org/citations/22229156 | http://purl.uniprot.org/core/author | "Pittoni P."xsd:string |
| http://purl.uniprot.org/citations/22229156 | http://purl.uniprot.org/core/author | "Gorzanelli A."xsd:string |
| http://purl.uniprot.org/citations/22229156 | http://purl.uniprot.org/core/author | "Burocchi A."xsd:string |
| http://purl.uniprot.org/citations/22229156 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22229156 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/22229156 | http://purl.uniprot.org/core/pages | "3615-3626"xsd:string |
| http://purl.uniprot.org/citations/22229156 | http://purl.uniprot.org/core/title | "Intratumor OX40 stimulation inhibits IRF1 expression and IL-10 production by Treg cells while enhancing CD40L expression by effector memory T cells."xsd:string |
| http://purl.uniprot.org/citations/22229156 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/22229156 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22229156 |
| http://purl.uniprot.org/citations/22229156 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22229156 |
| http://purl.uniprot.org/uniprot/#_P15314-mappedCitation-22229156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22229156 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GUQ3-mappedCitation-22229156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22229156 |
| http://purl.uniprot.org/uniprot/#_A2A5L7-mappedCitation-22229156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22229156 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EC35-mappedCitation-22229156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22229156 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EC46-mappedCitation-22229156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22229156 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EI60-mappedCitation-22229156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22229156 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4L2R0-mappedCitation-22229156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22229156 |
| http://purl.uniprot.org/uniprot/#_B1ASL3-mappedCitation-22229156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22229156 |
| http://purl.uniprot.org/uniprot/#_A8Y5B9-mappedCitation-22229156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22229156 |
| http://purl.uniprot.org/uniprot/#_D6RH71-mappedCitation-22229156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22229156 |