| http://purl.uniprot.org/citations/22231517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22231517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22231517 | http://www.w3.org/2000/01/rdf-schema#comment | "Memory T cells exert antigen-independent effector functions, but how these responses are regulated is unclear. We discovered an in vivo link between flagellin-induced NLRC4 inflammasome activation in splenic dendritic cells (DCs) and host protective interferon-γ (IFN-γ) secretion by noncognate memory CD8(+) T cells, which could be activated by Salmonella enterica serovar Typhimurium, Yersinia pseudotuberculosis and Pseudomonas aeruginosa. We show that CD8α(+) DCs were particularly efficient at sensing bacterial flagellin through NLRC4 inflammasomes. Although this activation released interleukin 18 (IL-18) and IL-1β, only IL-18 was required for IFN-γ production by memory CD8(+) T cells. Conversely, only the release of IL-1β, but not IL-18, depended on priming signals mediated by Toll-like receptors. These findings provide a comprehensive mechanistic framework for the regulation of noncognate memory T cell responses during bacterial immunity."xsd:string |
| http://purl.uniprot.org/citations/22231517 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.2195"xsd:string |
| http://purl.uniprot.org/citations/22231517 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.2195"xsd:string |
| http://purl.uniprot.org/citations/22231517 | http://purl.uniprot.org/core/author | "Cao H."xsd:string |
| http://purl.uniprot.org/citations/22231517 | http://purl.uniprot.org/core/author | "Cao H."xsd:string |
| http://purl.uniprot.org/citations/22231517 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/22231517 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/22231517 | http://purl.uniprot.org/core/author | "Strugnell R.A."xsd:string |
| http://purl.uniprot.org/citations/22231517 | http://purl.uniprot.org/core/author | "Strugnell R.A."xsd:string |
| http://purl.uniprot.org/citations/22231517 | http://purl.uniprot.org/core/author | "Tschopp J."xsd:string |
| http://purl.uniprot.org/citations/22231517 | http://purl.uniprot.org/core/author | "Tschopp J."xsd:string |
| http://purl.uniprot.org/citations/22231517 | http://purl.uniprot.org/core/author | "Curtiss R. III"xsd:string |
| http://purl.uniprot.org/citations/22231517 | http://purl.uniprot.org/core/author | "Curtiss R. III"xsd:string |
| http://purl.uniprot.org/citations/22231517 | http://purl.uniprot.org/core/author | "Guarda G."xsd:string |
| http://purl.uniprot.org/citations/22231517 | http://purl.uniprot.org/core/author | "Guarda G."xsd:string |
| http://purl.uniprot.org/citations/22231517 | http://purl.uniprot.org/core/author | "Bedoui S."xsd:string |
| http://purl.uniprot.org/citations/22231517 | http://purl.uniprot.org/core/author | "Bedoui S."xsd:string |
| http://purl.uniprot.org/citations/22231517 | http://purl.uniprot.org/core/author | "Whitney P.G."xsd:string |
| http://purl.uniprot.org/citations/22231517 | http://purl.uniprot.org/core/author | "Whitney P.G."xsd:string |
| http://purl.uniprot.org/citations/22231517 | http://purl.uniprot.org/core/author | "Kupz A."xsd:string |
| http://purl.uniprot.org/citations/22231517 | http://purl.uniprot.org/core/author | "Kupz A."xsd:string |
| http://purl.uniprot.org/citations/22231517 | http://purl.uniprot.org/core/author | "Heath W.R."xsd:string |
| http://purl.uniprot.org/citations/22231517 | http://purl.uniprot.org/core/author | "Heath W.R."xsd:string |