| http://purl.uniprot.org/citations/22232929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22232929 | http://www.w3.org/2000/01/rdf-schema#comment | "The contribution of the polymorphic markers of cytochrome P450 genes to respiratory diseases caused by smoking and occupational factors has been assessed. For this purpose, PCR-RFLP analysis of the CYP1B1 (rs1056836, 4326C > G), CYP2F1 (rs11399890, c.14_15insC), CYP2J2 (rs890293, -76G > T), and CYP2S1 (rs34971233, 13106C > T and rs338583, 13255A > G) gene polymorphisms has been performed. The analysis has shown that the polymorphic variants of the CYP1B1 (rs1056836, 4326C > G) and CYP2F1 (rs11399890, c. 14_15insC) genes may contribute to the development of occupational chronic bronchitis. The proportion of CYP1B1* 1*3 heterozygotes in the group of patients with occupational chronic bronchitis is considerably greater than in the group of healthy workers (69.16% versus 53.29%; chi2 = 5.94, P = 0.02, P(cor) = 0.04, OR = 1.97, the 95% CI is 1.13-3.42). Patients with occupational chronic bronchitis and healthy workers significantly differed from each other in the frequency distribution of the genotypes ofthe CYP2F1 (rs11399890, c.14_15insC) polymorphic marker (chi2 = 6.18, d.f = 2, P = 0.05). The frequency of the wild type/ins heterozygous genotype for the CYP2F1 gene is higher in healthy workers (36.08%) than in patients (22.22%) (chi2 = 5.48, P = 0.02, P(cor) = 0.04, OR = 0.51, the 95% CI is 0.28-0.90). No association has been found between the CYP2J2 (rs890293, -76G > T) or CYP2S1 (rs34971233, 13106C > T, P466L and rs338583, 13255A > G) gene polymorphisms and respiratory diseases."xsd:string |
| http://purl.uniprot.org/citations/22232929 | http://purl.uniprot.org/core/author | "Korytina G.F."xsd:string |
| http://purl.uniprot.org/citations/22232929 | http://purl.uniprot.org/core/author | "Victorova T.V."xsd:string |
| http://purl.uniprot.org/citations/22232929 | http://purl.uniprot.org/core/author | "Akhmadishina L.A."xsd:string |
| http://purl.uniprot.org/citations/22232929 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22232929 | http://purl.uniprot.org/core/name | "Genetika"xsd:string |
| http://purl.uniprot.org/citations/22232929 | http://purl.uniprot.org/core/pages | "1402-1410"xsd:string |
| http://purl.uniprot.org/citations/22232929 | http://purl.uniprot.org/core/title | "[Polymorphic markers of the CYP1B1 (4326C > G), CYP2F1 (c.14_15insC), CYP2J2 (-76G > T), and CYP2S1 (13106C > T and 13255A > G) genes and genetic predisposition to chronic respiratory diseases induced by smoking and occupational factors]."xsd:string |
| http://purl.uniprot.org/citations/22232929 | http://purl.uniprot.org/core/volume | "47"xsd:string |
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