| http://purl.uniprot.org/citations/22234691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22234691 | http://www.w3.org/2000/01/rdf-schema#comment | "The relationship between low-density lipoprotein receptor-related protein-1 (LRP1) and von Willebrand factor (VWF) has remained elusive for years. Indeed, despite a reported absence of interaction between both proteins, liver-specific deletion of LRP1 results in increased VWF levels. To investigate this discrepancy, we used mice with a macrophage-specific deficiency of LRP1 (macLRP1(-)) because we previously found that macrophages dominate VWF clearance. Basal VWF levels were increased in macLRP1(-) mice compared with control mice (1.6 ± 0.4 vs 1.0 ± 0.4 U/mL). Clearance experiments revealed that half-life of human VWF was significantly increased in macLRP1(-) mice. Ubiquitous blocking of LRP1 or additional lipoprotein receptors by overexpressing receptor-associated protein in macLRP1(-) mice did not result in further rise of VWF levels (0.1 ± 0.2 U/mL), in contrast to macLRP1(+) mice (rise in VWF, 0.8 ± 0.4 U/mL). This points to macLRP1 being the only lipoprotein receptor regulating VWF levels. When testing the mechanism(s) involved, we observed that VWF-coated beads adhered efficiently to LRP1 but only when exposed to shear forces exceeding 2.5 dyne/cm(2), implying the existence of shear stress-dependent interactions. Furthermore, a mechanism involving β2-integrins that binds both VWF and LRP1 also is implicated because inhibition of β2-integrins led to increased VWF levels in control (rise, 0.19 ± 0.16 U/mL) but not in macLRP1(-) mice (0.08 ± 0.15 U/mL)."xsd:string |
| http://purl.uniprot.org/citations/22234691 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2011-08-373605"xsd:string |
| http://purl.uniprot.org/citations/22234691 | http://purl.uniprot.org/core/author | "Denis C.V."xsd:string |
| http://purl.uniprot.org/citations/22234691 | http://purl.uniprot.org/core/author | "Legendre P."xsd:string |
| http://purl.uniprot.org/citations/22234691 | http://purl.uniprot.org/core/author | "Lenting P.J."xsd:string |
| http://purl.uniprot.org/citations/22234691 | http://purl.uniprot.org/core/author | "van Vlijmen B.J."xsd:string |
| http://purl.uniprot.org/citations/22234691 | http://purl.uniprot.org/core/author | "Christophe O.D."xsd:string |
| http://purl.uniprot.org/citations/22234691 | http://purl.uniprot.org/core/author | "Navarrete A.M."xsd:string |
| http://purl.uniprot.org/citations/22234691 | http://purl.uniprot.org/core/author | "Casari C."xsd:string |
| http://purl.uniprot.org/citations/22234691 | http://purl.uniprot.org/core/author | "Odouard S."xsd:string |
| http://purl.uniprot.org/citations/22234691 | http://purl.uniprot.org/core/author | "Pegon J.N."xsd:string |
| http://purl.uniprot.org/citations/22234691 | http://purl.uniprot.org/core/author | "Rastegarlari G."xsd:string |
| http://purl.uniprot.org/citations/22234691 | http://purl.uniprot.org/core/author | "Saint-Lu N."xsd:string |
| http://purl.uniprot.org/citations/22234691 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22234691 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/22234691 | http://purl.uniprot.org/core/pages | "2126-2134"xsd:string |
| http://purl.uniprot.org/citations/22234691 | http://purl.uniprot.org/core/title | "Macrophage LRP1 contributes to the clearance of von Willebrand factor."xsd:string |
| http://purl.uniprot.org/citations/22234691 | http://purl.uniprot.org/core/volume | "119"xsd:string |
| http://purl.uniprot.org/citations/22234691 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22234691 |
| http://purl.uniprot.org/citations/22234691 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22234691 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0I9-mappedCitation-22234691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22234691 |
| http://purl.uniprot.org/uniprot/#_A0A077S2U6-mappedCitation-22234691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22234691 |
| http://purl.uniprot.org/uniprot/#_D3YW61-mappedCitation-22234691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22234691 |
| http://purl.uniprot.org/uniprot/#_D3Z5M3-mappedCitation-22234691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22234691 |