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http://purl.uniprot.org/citations/22234932http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22234932http://www.w3.org/2000/01/rdf-schema#comment"

Unlabelled

We performed a review of public microarray data that revealed a significant down-regulation of Rnd3 expression in hepatocellular carcinoma (HCC), as compared to nontumor liver. Rnd3/RhoE is an atypical RhoGTPase family member because it is always under its active GTP-bound conformation and not sensitive to classical regulators. Rnd3 down-regulation was validated by quantitative real-time polymerase chain reaction in 120 independent tumors. Moreover, Rnd3 down-expression was confirmed using immunohistochemistry on tumor sections and western blotting on human tumor and cell-line extracts. Rnd3 expression was significantly lower in invasive tumors with satellite nodules. Overexpression and silencing of Rnd3 in Hep3B cells led to decreased and increased three-dimensional cell motility, respectively. The short interfering RNA-mediated down-regulation of Rnd3 expression induced a loss of E-cadherin at cell-cell junctions that was linked to epithelial-mesenchymal transition through the up-regulation of the zinc finger E-box binding homeobox protein, ZEB2, and the down-regulation of miR-200b and miR-200c. Rnd3 knockdown mediated tumor hepatocyte invasion in a matrix-metalloproteinase-independent, and Rac1-dependent manner.

Conclusion

Rnd3 down-regulation provides an invasive advantage to tumor hepatocytes, suggesting that RND3 might represent a metastasis suppressor gene in HCC."xsd:string
http://purl.uniprot.org/citations/22234932http://purl.org/dc/terms/identifier"doi:10.1002/hep.25568"xsd:string
http://purl.uniprot.org/citations/22234932http://purl.uniprot.org/core/author"Moreau V."xsd:string
http://purl.uniprot.org/citations/22234932http://purl.uniprot.org/core/author"Rosenbaum J."xsd:string
http://purl.uniprot.org/citations/22234932http://purl.uniprot.org/core/author"Bioulac-Sage P."xsd:string
http://purl.uniprot.org/citations/22234932http://purl.uniprot.org/core/author"Zucman-Rossi J."xsd:string
http://purl.uniprot.org/citations/22234932http://purl.uniprot.org/core/author"Makki K."xsd:string
http://purl.uniprot.org/citations/22234932http://purl.uniprot.org/core/author"Grise F."xsd:string
http://purl.uniprot.org/citations/22234932http://purl.uniprot.org/core/author"Staedel C."xsd:string
http://purl.uniprot.org/citations/22234932http://purl.uniprot.org/core/author"Sena S."xsd:string
http://purl.uniprot.org/citations/22234932http://purl.uniprot.org/core/author"Dugot-Senant N."xsd:string
http://purl.uniprot.org/citations/22234932http://purl.uniprot.org/core/author"Baud J."xsd:string
http://purl.uniprot.org/citations/22234932http://purl.uniprot.org/core/author"Bidaud-Meynard A."xsd:string
http://purl.uniprot.org/citations/22234932http://purl.uniprot.org/core/author"Hiriart J.B."xsd:string
http://purl.uniprot.org/citations/22234932http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22234932http://purl.uniprot.org/core/name"Hepatology"xsd:string
http://purl.uniprot.org/citations/22234932http://purl.uniprot.org/core/pages"1766-1775"xsd:string
http://purl.uniprot.org/citations/22234932http://purl.uniprot.org/core/title"Rnd3/RhoE Is down-regulated in hepatocellular carcinoma and controls cellular invasion."xsd:string
http://purl.uniprot.org/citations/22234932http://purl.uniprot.org/core/volume"55"xsd:string
http://purl.uniprot.org/citations/22234932http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22234932
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http://purl.uniprot.org/uniprot/#_P61587-mappedCitation-22234932http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22234932
http://purl.uniprot.org/uniprot/#_B2R838-mappedCitation-22234932http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22234932
http://purl.uniprot.org/uniprot/#_B4DSG7-mappedCitation-22234932http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22234932
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