| http://purl.uniprot.org/citations/22246030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22246030 | http://www.w3.org/2000/01/rdf-schema#comment | "Endothelial cells (ECs) express 2 members of the cadherin family, VE and N-cadherin. Although VE-cadherin induces EC homotypic adhesion, N-cadherin function in ECs remains largely unknown. EC-specific inactivation of either VE or N-cadherin leads to early fetal lethality suggesting that these cadherins play a nonredundant role in vascular development. We report here that VE-cadherin negatively controls junctional localization and expression of N-cadherin by limiting p120-catenin availability and reducing β-catenin transcriptional activity. Using EC lines expressing either VE or N-cadherin we found that both cadherins inhibit cell proliferation and apoptosis. Both trigger the phosphatidylinositol-3-OH-kinase (PI3K)-AKT-Forkhead-box protein-O1 (FoxO1) pathway and reduce β-catenin transcriptional activity. The extent of signaling correlates with the total level of cadherins regardless of the type of cadherin expressed. In contrast, basal and fibroblast growth factor (FGF)-induced cell motility is promoted by N-cadherin and strongly inhibited by VE-cadherin. This opposite effect is partly because of the ability of VE-cadherin to associate with FGF receptor and the density-enhanced phosphatase-1 (Dep-1) which, in turn, inhibits receptor signaling. We conclude that VE and N-cadherin have both additive and divergent effects on ECs. Differences in signaling are due, in part, to cadherin association with growth factor receptors and modulation of their downstream signaling."xsd:string |
| http://purl.uniprot.org/citations/22246030 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2011-09-381012"xsd:string |
| http://purl.uniprot.org/citations/22246030 | http://purl.uniprot.org/core/author | "Taddei A."xsd:string |
| http://purl.uniprot.org/citations/22246030 | http://purl.uniprot.org/core/author | "Cavallaro U."xsd:string |
| http://purl.uniprot.org/citations/22246030 | http://purl.uniprot.org/core/author | "Corada M."xsd:string |
| http://purl.uniprot.org/citations/22246030 | http://purl.uniprot.org/core/author | "Dejana E."xsd:string |
| http://purl.uniprot.org/citations/22246030 | http://purl.uniprot.org/core/author | "Lampugnani M.G."xsd:string |
| http://purl.uniprot.org/citations/22246030 | http://purl.uniprot.org/core/author | "Orsenigo F."xsd:string |
| http://purl.uniprot.org/citations/22246030 | http://purl.uniprot.org/core/author | "Giampietro C."xsd:string |
| http://purl.uniprot.org/citations/22246030 | http://purl.uniprot.org/core/author | "Alcalay M."xsd:string |
| http://purl.uniprot.org/citations/22246030 | http://purl.uniprot.org/core/author | "Sarra-Ferraris G.M."xsd:string |
| http://purl.uniprot.org/citations/22246030 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22246030 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/22246030 | http://purl.uniprot.org/core/pages | "2159-2170"xsd:string |
| http://purl.uniprot.org/citations/22246030 | http://purl.uniprot.org/core/title | "Overlapping and divergent signaling pathways of N-cadherin and VE-cadherin in endothelial cells."xsd:string |
| http://purl.uniprot.org/citations/22246030 | http://purl.uniprot.org/core/volume | "119"xsd:string |
| http://purl.uniprot.org/citations/22246030 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22246030 |
| http://purl.uniprot.org/citations/22246030 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22246030 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQW9-mappedCitation-22246030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22246030 |
| http://purl.uniprot.org/uniprot/#_D3YYT0-mappedCitation-22246030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22246030 |
| http://purl.uniprot.org/uniprot/#_A2AWF8-mappedCitation-22246030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22246030 |
| http://purl.uniprot.org/uniprot/#_A2AWF9-mappedCitation-22246030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22246030 |
| http://purl.uniprot.org/uniprot/#_E9Q4S7-mappedCitation-22246030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22246030 |
| http://purl.uniprot.org/uniprot/#_Q61373-mappedCitation-22246030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22246030 |